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dc.creator Yelamarthi, Tripura
dc.date.accessioned 2012-06-28T18:35:10Z
dc.date.available 2012-06-28T18:35:10Z
dc.date.created 2012-05
dc.date.issued 2012-06-28
dc.date.submitted May 2012
dc.identifier.uri http://hdl.handle.net/10657/ETD-UH-2012-05-418
dc.description.abstract The purpose of this study is to test the biomechanical properties of the rat (Rattus norvegicus) medial collateral ligament (MCL) following knee surgery and healing with the aid of Insulin-like growth factor (IGF-1) gene therapy treatments. The research work consisted of three stages: First, the design of a novel de novo technique that captures both static and dynamic characteristics of the knee ligament. Second, validation tests of this experimental apparatus were performed to show the repeatability of the measurements. Third, we measured the static characteristics, such as stiffness and strength and the dynamic characteristics, such as frequency and operating deflection shapes, of newly healed ligaments. Based on our analysis, surgically disrupted ligaments treated with the scAAV2-IGF-1b gene therapy treatment for three weeks displayed increases in ligament strength and toughness, suggesting that IGF-1b gene therapy may be a viable post-surgical treatment countermeasure for ligament repair.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subject Laser Doppler Vibrometry,Medial Collateral Ligament
dc.title STATIC AND DYNAMIC CHARACTERIZATION OF THE LIGAMENT SUBJECTED TO ALTERNATIVE WOUND HEALING
dc.date.updated 2012-06-28T18:35:13Z
dc.identifier.slug 10657/ETD-UH-2012-05-418
dc.type.material text *
dc.type.genre thesis *
thesis.degree.name Aerospace ENGR (MS)
thesis.degree.level Masters
thesis.degree.discipline Mechanical
thesis.degree.grantor University of Houston
thesis.degree.department Mechanical Engineering

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