Welcome to the UT Southwestern Institutional Repository, which collects, preserves, and distributes digital material pertaining to the clinical, educational, and research missions of the university. Repositories are important tools for preserving an organization's legacy; they facilitate digital preservation and scholarly communication.
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The Hydrophobic Handoff Between NPC2 and the N-Terminal Domain of NPC1 in the Export of Cholesterol from Lysosomes (2013-05)Low density lipoproteins (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes where its cholesterol is released. ...
Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors (2013-05)Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells ...
(2013-05)A20 is a potent anti-inflammatory protein that inhibits NF-ΚB, and A20 dysfunction is associated with autoimmunity and B-cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ multiple mechanisms to ...
(2013-05)MicroRNAs are small RNAs approximately 20-24 nucleotides in length that are conserved throughout evolution. MicroRNA genes are transcribed by RNA polymerase II and are processed both in the nucleus and the cytoplasm from ...