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dc.contributor.advisorLacritz, Laura H.en
dc.creatorRossetti, Heidi Christineen
dc.date.accessioned2010-07-12T19:03:18Zen
dc.date.available2010-07-12T19:03:18Zen
dc.date.issued2007-08-08en
dc.identifier.other756836626en
dc.identifier.urihttp://hdl.handle.net/2152.5/784en
dc.description.abstractThe Consortium to Establish a Registry for Alzheimer's Disease (CERAD) created a neuropsychological battery that is both brief and sensitive to dementia (Morris et al., 1989). Chandler et al. (2005) put forth a method of calculating a Total Score for the CERAD along with normative data. The objective of this study was to determine the utility of the Total Score as a measure of progression of Alzheimer's disease (AD). Subjects included CERAD registry normal controls (NC; N = 383) and AD subjects (N = 655) with a baseline assessment and at least one follow-up assessment. Change Scores were calculated along with Reliable Change Indexes (RCI). The AD sample declined an average of -7.2 points per year, compared to a 1.0 point annual increase obtained by the NC sample. By the third annual assessment, the majority of AD subjects (65.2%) exceeded the confidence interval established by the RCI. Annualized CERAD Change Scores significantly correlated with change scores on the MMSE (r = .66), CDR Sum of Boxes (r = -.42), and BDRS (r = -.38). The impact of race, gender, education, and age-at-baseline on AD progression was examined with analysis of covariance and multiple regression. Demographic variables accounted for only 4% of the variance in annualized change in CERAD performance, with greater annualized decline in Total Score observed in Caucasians (M = -7.64, SD = 6.82) versus African- Americans (M = -4.60, SD = 7.03); males (M = -8.22, SD = 6.70) versus females (M = 6-.44, SD = 7.04); and younger age-at-baseline (M = -8.72, SD = 6.44) versus older age-at-baseline (M = -6.85, SD = 7.01). Neither education nor dementia severity significantly impacted annualized Change Scores. The current study provides support for the validity of the CERAD Total Score as a measure of progression in AD.en
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.subjectAlzheimer Diseaseen
dc.subjectNeuropsychological Testsen
dc.subjectDemographic Analysesen
dc.titleUtility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Diseaseen
dc.type.materialTexten
dc.type.genreThesisen
dc.format.digitalOriginborn digitalen
thesis.degree.grantorGraduate School of Biomedical Sciencesen
thesis.degree.departmenten
thesis.degree.nameMaster of Scienceen
thesis.degree.levelM.S.en
thesis.degree.disciplineRehabilitation Counseling Psychologyen
thesis.date.available2007-08-08en


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