Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease

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Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease

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dc.contributor.advisor Lacritz, Laura en
dc.creator Rossetti, Heidi Christine en
dc.date.accessioned 2010-07-12T19:03:18Z en
dc.date.available 2010-07-12T19:03:18Z en
dc.date.issued 2007-08-08 en
dc.identifier.other 756836626 en
dc.identifier.uri http://hdl.handle.net/2152.5/784 en
dc.description.abstract The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) created a neuropsychological battery that is both brief and sensitive to dementia (Morris et al., 1989). Chandler et al. (2005) put forth a method of calculating a Total Score for the CERAD along with normative data. The objective of this study was to determine the utility of the Total Score as a measure of progression of Alzheimer's disease (AD). Subjects included CERAD registry normal controls (NC; N = 383) and AD subjects (N = 655) with a baseline assessment and at least one follow-up assessment. Change Scores were calculated along with Reliable Change Indexes (RCI). The AD sample declined an average of -7.2 points per year, compared to a 1.0 point annual increase obtained by the NC sample. By the third annual assessment, the majority of AD subjects (65.2%) exceeded the confidence interval established by the RCI. Annualized CERAD Change Scores significantly correlated with change scores on the MMSE (r = .66), CDR Sum of Boxes (r = -.42), and BDRS (r = -.38). The impact of race, gender, education, and age-at-baseline on AD progression was examined with analysis of covariance and multiple regression. Demographic variables accounted for only 4% of the variance in annualized change in CERAD performance, with greater annualized decline in Total Score observed in Caucasians (M = -7.64, SD = 6.82) versus African- Americans (M = -4.60, SD = 7.03); males (M = -8.22, SD = 6.70) versus females (M = 6-.44, SD = 7.04); and younger age-at-baseline (M = -8.72, SD = 6.44) versus older age-at-baseline (M = -6.85, SD = 7.01). Neither education nor dementia severity significantly impacted annualized Change Scores. The current study provides support for the validity of the CERAD Total Score as a measure of progression in AD. en
dc.format.medium Electronic en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.subject Alzheimer Disease en
dc.subject Neuropsychological Tests en
dc.subject Demographic Analyses en
dc.title Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease en
dc.type.material Text en
dc.type.genre Thesis en
dc.format.digitalOrigin born digital en
thesis.degree.grantor Graduate School of Biomedical Sciences en
thesis.degree.department en
thesis.degree.name Master of Science en
thesis.degree.level M.S. en
thesis.degree.discipline Rehabilitation Counseling Psychology en
thesis.date.available 2007-08-08 en

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