Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube

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Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube

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dc.contributor.advisor Lu, Q. Richard en
dc.creator Collisson, Tandi Louise en
dc.date.accessioned 2010-07-12T19:00:19Z en
dc.date.available 2010-07-12T19:00:19Z en
dc.date.issued 2003-05-01 en
dc.identifier.other 59227025 en
dc.identifier.uri http://hdl.handle.net/2152.5/762 en
dc.description.abstract Neural-specific Class II bHLH transcription factors heterodimerize with ubiquitous Class I bHLH E proteins to form complexes required for neural differentiation. There are four known E proteins, HEB, E12, E47 and E2.2, in the mammalian nervous system, which potentially form heterodimers with Mash1 in the neural tube. To test the relevance of particular Mash1-E protein heterodimer combinations in vivo, I constructed tethered Mash1-E protein heterodimers for over-expression in the chick neural tube. By comparing overexpression of Mash1 with over-expression of these Mash1-E protein heterodimers, their abilities to effect neural differentiation and cell-type specification were analyzed. Mash1-E protein heterodimers are interchangeable in the function of driving neurogenesis in the chick neural tube. The effects of Mash1-E protein heterodimers on cell-type specificity were different, suggesting non-redundant functions in effecting dorsal interneuron populations. Furthermore, additional Mash1 heterodimer partners may be required for the cell-type specification function of Mash1. en
dc.format.medium Electronic en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.subject Neurogenesis en
dc.subject Interneurons en
dc.subject Basic Helix-Loop-Helix Transcription Factors en
dc.title Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube en
dc.type.material Text en
dc.type.genre dissertation en
dc.format.digitalOrigin born digital en
thesis.degree.grantor Graduate School of Biomedical Sciences en
thesis.degree.department en
thesis.degree.name Master of Science en
thesis.degree.level M.S. en
thesis.degree.discipline Neuroscience en
thesis.date.available 2004-04-23 en

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