Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis

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Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis

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dc.contributor.advisor Niederkorn, Jerry Y. en
dc.creator Hurt, Michael Allen en
dc.date.accessioned 2010-07-12T17:32:30Z en
dc.date.available 2010-07-12T17:32:30Z en
dc.date.issued 2004-01-14 en
dc.identifier.other 60327516 en
dc.identifier.uri http://hdl.handle.net/2152.5/312 en
dc.description.abstract Acanthamoeba spp. are ubiquitously distributed in the environment. The trophozoite form can infect the cornea and cause sight-threatening corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of Acanthamoeba keratitis begins when Acanthamoebae bind to mannose expressed on traumatized corneas. Published reports indicate that mannose is upregulated on the corneal surface during wound healing. Experiments in laboratory animals have shown that corneal abrasion prior to infection is essential for generating Acanthamoeba keratitis. Furthermore, supernatants from Acanthamoeba en
dc.format.medium Electronic en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.subject Eye Infections, Parasitic en
dc.subject Acanthamoeba Keratitis en
dc.subject Protozoan Proteins en
dc.title Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis en
dc.type.material Text en
dc.type.genre dissertation en
dc.format.digitalOrigin born digital en
thesis.degree.grantor Graduate School of Biomedical Sciences en
thesis.degree.department en
thesis.degree.name Doctor of Philosophy en
thesis.degree.level Ph.D. en
thesis.degree.discipline Molecular Microbiology en
thesis.date.available 2005-01-14 en

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