GATA Co-Factors : Collaborators in Cardiac Development, Conspirators in Cardiac Disease

DSpace/Manakin Repository

GATA Co-Factors : Collaborators in Cardiac Development, Conspirators in Cardiac Disease

Show full item record


Title: GATA Co-Factors : Collaborators in Cardiac Development, Conspirators in Cardiac Disease
Author: Kathiriya, Irfan S.
Abstract: Disruption of fetal gene expression during cardiac development can result in congenital heart defects (CHDs), the most common developmental anomaly in humans and the leading non-infectious cause of death in newborns. The reactivation of fetal gene expression during cardiac hypertrophy in the adult is an adaptive response to pressure or volume overloads, but can lead to impaired cardiac function. Gata4, a member of a family of zinc-finger transcription factors, has been implicated as a key regulator of fetal cardiac gene expression during cardiac development and cardiac hypertrophy. This thesis work presents two novel transcriptional complexes likely found in these settings, one that cooperates to activate GATA-dependent transactivation and one that represses it.
URI: http://hdl.handle.net/2152.5/292
Date: 2005-05-03

Files in this item

Files Size Format View
kathiriyairfan.pdf 7.803Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record

Search DSpace


Advanced Search

Browse

My Account