Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration

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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration

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dc.contributor.advisor Haley, Robert en
dc.creator Nettune, Gregory en
dc.date.accessioned 2010-07-12T16:19:02Z en
dc.date.available 2010-07-12T16:19:02Z en
dc.date.issued 2006-10-13 en
dc.identifier.other en
dc.identifier.uri http://hdl.handle.net/2152.5/214 en
dc.description.abstract Purpose: Age-related macular degeneration (ARMD) is a leading cause of irreversible blindness in the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the risk of progression to exudative ARMD in a matched case-control study. Methods: An epidemiological study of 61 cases with exudative ARMD matched by age, gender, and race to 61 controls with early, high-risk ARMD determined by prospective ophthalmologic examination. Results: The risk of exudative ARMD was increased by smoking within the past 20 years (OR=5.8, 95% CI 1.42-23.77) and reduced by use of statins (OR=0.2, 95% CI 0.04-0.93). Further, the duration of statin use up to four years was associated with an increasing degree of protection (9% reduction each month, 95% CI 0.85-0.98). Conclusion: Statin use may reduce the progression from dry to exudative ARMD. en
dc.format.medium Electronic en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.subject Macular Degeneration en
dc.subject Blindness en
dc.subject Hydroxymethylglutaryl-CoA Reductase Inhibitors en
dc.title Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration en
dc.type.material Text en
dc.type.genre dissertation en
dc.format.digitalOrigin born digital en
thesis.degree.grantor Southwestern Medical School en
thesis.degree.name M.D. with Distinction en
thesis.degree.level Doctoral en
thesis.degree.discipline Research en
thesis.date.available 2007-10-13 en

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