Now showing items 1-2 of 2

  • Gene Targeting in a Novel Mouse Model and the Chicken DT40 Cell Line 

    Connelly, Jon Patrick (2010-05-14)
    Gene targeting has the power to create precise changes at specific sites within the genome. In the context of gene therapy, this technology may be used to treat patients with monogenic diseases by fixing mutations in disease ...
  • Optimizing Zinc Finger Nucleases for Use in Mammalian Cells 

    Pruett-Miller, Shondra M. (2009-01-14)
    Homologous recombination is a well-established technique that has been used to manipulate the genomes of multiple model organisms with great precision and is therefore being explored as a potential way of performing gene ...