Now showing items 1-4 of 4

    • Improving Profile Similarity Search and Alignment of Protein Sequences 

      Tong, Jing; 0000-0001-9680-3526 (2015-11-20)
      Protein function prediction is one of the most important problems in the field of computational biology. The most reliable method to predict protein function is to detect homologs. Homologous proteins tend to possess ...
    • On Two Problems in Comparative Genomics of Eukaryotes 

      Semeiks, Jeremy Raymond (2013-05-23)
      The recent advent of whole-genome sequencing allows us to use novel comparative methods to explore the genetic bases for traits of interest. Here, I present two case studies of such methods applied to eukaryote genomes. The ...
    • Optimization and Analysis of Weighted-Window Predictors of Structural Disorder in Proteins 

      Holladay, Nathan Brent (2007-05-22)
      X-ray crystallographic protein structures often contain disordered regions that are observed as missing electron density. We have developed single sequence and profile-based weighted-window predictors of structural disorder ...
    • Towards Prediction of Phenotype from Genotype 

      Cong, Qian; 0000-0002-8909-0414 (2017-04-14)
      Predicting phenotype from genotype represents the epitome of biological questions. As a multiscale problem, it starts from predicting exons and culminates with modeling of whole organisms. Focusing on the molecular level, ...