Now showing items 1-4 of 4

    • Effects of Glucose and Free Fatty Acids on ERK1/2 in Pancreatic B-Cells 

      Arnette, Donald Ervin, Jr. (2005-05-04)
      Diabetes is a growing problem in the United States. There is a growing occurrence of obesity in the United States, which directly adds to the incidence and occurrence of diabetes. Our lab has previously showed that the ...
    • Exploration of Chemical and Biochemical Mechanisms of Catalysis 

      Cormier, Kevin William (2013-07-25)
      Nature uses proteins to catalyze a wide range of chemical processes that control cellular signaling. One such enzyme is ERK2 which plays a role in the transmission of signals by catalyzing the phosphorylation of its ...
    • Kinetics and Regulation of Protein Kinases 

      Piala, Alexander Townshend; 0000-0002-8518-3760 (2015-06-23)
      One of the major functions of kinases in biological systems is the relay of signal from an effector to a downstream target. Kinases are regulated by a diversity of mechanisms, both internal and external to the kinase. When ...
    • Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP 

      Chen, Chiyuan (2007-08-08)
      The RAF/MEK/MAP Kinase signal transduction cascade is the most extensively studied MAPK pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic ...