Browsing UT Southwestern Electronic Theses and Dissertations by Title
Now showing items 866-885 of 948
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Targeted Molecular Imaging: A Guide to Combination Therapy
(2006-12-20)Recombinant adenovirus is widely used to deliver genes for cancer gene therapy. Coxsackie and Adenovirus' Receptor (CAR) is the primary receptor for recombinant adenovirus. Little attention has been paid to determine CAR ... -
Targeting Aminophospholipids Exposed on Tumor Endothelium for Tumor Imaging
(2012-07-20)Advances in noninvasive imaging of human cancer are crucial to improving diagnosis and therapeutic planning. My project was aimed at developing novel imaging agents that target the aminophospholipidsphosphatidylserine ... -
Targeting Nanoparticles to Tumor Vasculature
(2008-09-18)Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use ... -
TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
(2012-07-20)TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive ... -
Telomere Dynamics and End Processing in Mammalian Cells
(2006-05-15)Telomeres are repetitive DNA sequences that end in single-stranded 3' overhangs. With each cell division, normal human cells lose a small amount of telomeric DNA due to the end-replication problem and the action of an ... -
Telomere Length Studies in Human Cancer Cells
(2011-08-10)Telomeres consist of repetitive DNA sequences and their associated binding proteins, and serve to protect linear chromosome ends from being recognized as double stranded breaks in need of repair. The telomeres of most ... -
Telomere Position Effect in Human Cells
(2003-04-01)Telomeres are tracts of repetitive DNA that cap the ends of linear chromosomes. Each time the chromosome is duplicated, a small amount of telomeric DNA is lost from the end due to factors inherent in the mechanism of DNA ... -
Telomere Specific Homologous Recombination in the Alternative Lengthening of Telomeres
(2013-01-16)Over twenty years have passed since the discovery of telomerase-independent telomere maintenance, yet the precise details of the ALT mechanism remain a mystery. A growing body of evidence suggests that ALT cells maintain ... -
The Perceptions of Shared Medical Appointments among Health Care Workers at Parkland Hospital's Community Oriented Primary Care Clinics
(2014-05-22)Introduction: Shared Medical Appointments (SMAs) are a novel way of delivering health care to patients in a group setting. Past research regarding SMA quality improvement have always been patient focused. There is a great ... -
The Response of White Adipose Progenitor Cells to Physiological and Genetic Changes
(2013-02-21)We are in the midst of a dire, unprecedented and global epidemic of obesity and secondary sequelae, most prominently diabetes and hyperlipidemia. Underlying this epidemic are adipocytes and their inherent, dynamic ability ... -
Tissue-Specific Transplantation Antigens: Structurally Unique Isoforms of MHC-Related Proteins in Immunologically Tolerant Milieus
(2009-01-14)The immune network of the small intestine must maintain tolerance to an immense and diverse community of commensal microorganisms and a broad array of dietary antigens while constantly at the ready for insult from a variety ... -
Titanium-Mediated Carbometallation of Homoallylic Alcohols
(2012-07-20)Addition of zinc dichloride as an additive allows for the titanium-mediated carbometalation of homoallylic alcohols with Grignard reagents. The zinc dichloride additive successfully inhibits the B-hydride elimination of ... -
To Develop a Small Interfering RNA (siRNA) Design and Information Resource to Facilitate Genetic Manipulaton of Human Cells
(2004-05-25)Part I: Small interfering RNAs (siRNAs) have revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdown of gene expression. In the ... -
Tower of California Performance Early in Parkinson's Disease
(2008-09-19)Cognitive impairment associated with Parkinson's disease (PD) is widely described in the literature. Executive dysfunction has been reported even when the patients are not experiencing dementia. A significant (24% - 50+%) ... -
Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
(2009-01-09)In vertebrates, the heart is the first organ to function and cardiac progenitors are among the first cell lineages to be established. Transcriptional networks control the specification of cardiac progenitors, however, it ... -
Transcriptional and Translational Regulation of Heart Development in Mammals
(2008-09-18)The heart is the first organ to form in the embryo to support the growing need for oxygen and nutrients. To form correctly, this vital organ requires a high degree of regulation. Thus far, almost every known form of ... -
Transcriptional Gene Silencing in Mammalian Cells by MicroRNAs That Target Gene Promoters
(2011-08-10)A rich history exists for RNA-based regulation of gene transcription. It was reported more than a decade ago that RNA is capable of inducing DNA methylation and transcriptional gene silencing in plants. It was subsequently ... -
Transcriptional Profiling of Early Cardiac Development
(2005-08-11)Cardiogenesis is an intricate process that spans nearly the entire developmental history of the mammal. A thorough comprehension of the molecular interactions that direct cardiac development will improve our ability to ... -
Transcriptional Regulation During Cardiovascular Development
(2007-05-23)Heart development is a complex and tightly regulated process involving cell-fate specification, differentiation, and organogenesis. A network of transcription factors play pivotal roles in regulating each step during ... -
Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
(2011-08-10)Neurogenesis in the adult brain is a complex and lifelong process that is regulated by multiple pathways and is sensitive to many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. ...