Browsing UT Southwestern Electronic Theses and Dissertations by Title
Now showing items 1118-1137 of 1222
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Tackling Computational Challenges in High-Throughput RNA Interference Screening
(2014-04-07)Since the discovery of RNAi decades ago, it has been increasingly used in biomedical and biological research. The success of analyzing single genes using siRNAs has resulted in the large-scale application of RNAi for ... -
Targeted Molecular Imaging: A Guide to Combination Therapy
(2006-12-20)Recombinant adenovirus is widely used to deliver genes for cancer gene therapy. Coxsackie and Adenovirus' Receptor (CAR) is the primary receptor for recombinant adenovirus. Little attention has been paid to determine CAR ... -
Targeting Aminophospholipids Exposed on Tumor Endothelium for Tumor Imaging
(2012-07-20)Advances in noninvasive imaging of human cancer are crucial to improving diagnosis and therapeutic planning. My project was aimed at developing novel imaging agents that target the aminophospholipidsphosphatidylserine ... -
Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
(2015-08-03)Surgical resection followed by radiation and adjuvant temozolomide (TMZ) is the standard of care for glioblastoma (GBM). Not all GBMs respond to therapy, and most of them quickly acquire resistance to TMZ and recur. In ... -
Targeting Nanoparticles to Tumor Vasculature
(2008-09-18)Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use ... -
TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
(2012-07-20)TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive ... -
Telomere Dynamics and End Processing in Mammalian Cells
(2006-05-15)Telomeres are repetitive DNA sequences that end in single-stranded 3' overhangs. With each cell division, normal human cells lose a small amount of telomeric DNA due to the end-replication problem and the action of an ... -
Telomere Length Studies in Human Cancer Cells
(2011-08-10)Telomeres consist of repetitive DNA sequences and their associated binding proteins, and serve to protect linear chromosome ends from being recognized as double stranded breaks in need of repair. The telomeres of most ... -
Telomere Length, Uncommon Genetic Variation, and Depression
(2015-07-20)Previous research attempting to better understand the genetic basis of depression has demonstrated few clear findings. The present study employed a cross-sectional design to analyze the association between leukocyte telomere ... -
Telomere Position Effect in Human Cells
(2003-04-01)Telomeres are tracts of repetitive DNA that cap the ends of linear chromosomes. Each time the chromosome is duplicated, a small amount of telomeric DNA is lost from the end due to factors inherent in the mechanism of DNA ... -
Telomere Specific Homologous Recombination in the Alternative Lengthening of Telomeres
(2013-01-16)Over twenty years have passed since the discovery of telomerase-independent telomere maintenance, yet the precise details of the ALT mechanism remain a mystery. A growing body of evidence suggests that ALT cells maintain ... -
Tests of the Interpersonal Psychological Theory of Suicide among Adolescents
(2015-07-17)Self-injurious behaviors tend to first manifest during adolescence, marking this developmental period as an important context for suicide research. The lack of theory-driven research in this area has made it difficult to ... -
Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
(2014-04-08)The acquisition of pro-inflammatory phenotypes constitutes a checkpoint in the progression toward autoimmunity. Small molecule inhibitors of γ-secretase (γSI) have been shown to suppress TH1 differentiation and reduce the ... -
Tissue-Specific Transplantation Antigens: Structurally Unique Isoforms of MHC-Related Proteins in Immunologically Tolerant Milieus
(2009-01-14)The immune network of the small intestine must maintain tolerance to an immense and diverse community of commensal microorganisms and a broad array of dietary antigens while constantly at the ready for insult from a variety ... -
Titanium-Mediated Carbometallation of Homoallylic Alcohols
(2012-07-20)Addition of zinc dichloride as an additive allows for the titanium-mediated carbometalation of homoallylic alcohols with Grignard reagents. The zinc dichloride additive successfully inhibits the B-hydride elimination of ... -
To Develop a Small Interfering RNA (siRNA) Design and Information Resource to Facilitate Genetic Manipulaton of Human Cells
(2004-05-25)Part I: Small interfering RNAs (siRNAs) have revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdown of gene expression. In the ... -
A TOG:αβ-Tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase
(2012-12-04)Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that use alpha/beta-tubulin-interacting TOG (tumor overexpressed gene) domains to catalyze fast microtubule growth. Catalysis requires that ... -
Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
(2014-04-14)Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control activation and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage ... -
Total Synthesis of the Unique Pederin Family Member Psymberin & Chemical Studies Toward Saliniketal Family Members: Saliniketal a, Salinisporamycin and Rifsaliniketal
(2013-11-04)This manuscript consists of six chapters. The first four chapters involve the psymberin/irciniastatin A project. Psymberin was isolated from a psammoncinal sponge possessing an unprecedented differential cytotoxicity ... -
Towards Prediction of Phenotype from Genotype
(2017-04-14)Predicting phenotype from genotype represents the epitome of biological questions. As a multiscale problem, it starts from predicting exons and culminates with modeling of whole organisms. Focusing on the molecular level, ...