Now showing items 1-5 of 5

  • Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival 

    Topp, Justin David (2005-04-29)
    The transport of proteins between organelles is a highly regulated and complex process that is crucial for many of the functions required for cellular homeostasis. Many distinct proteins are involved in each trafficking ...
  • How to Mend a Broken Heart: Massive Endocytosis and the Role of Lipidic Forces in Membrane Trafficking 

    Fine, Michael Jon (2012-07-20)
    Novel forms of membrane internalization defined as massive endocytosis (MEND) were characterized for mechanism and physiological significance in isolated cells and intact cardiac tissue. These non-canonical forms of membrane ...
  • Rab5 Activation by the Vps9 Domain 

    Carney, Darren Scott (2007-05-21)
    The movement of proteins through the endocytic pathway is a complex and highly regulated process. Not only is this pathway used to internalize cellular nutrients, but it is also used to modulate a cell's response to ...
  • Regulation of Endocytic Recycling by FGD4, a Cdc42 GEF 

    Cardenas, Jessica A. (2012-07-10)
    The family of Receptor Tyrosine Kinases (RTKs) are a group of cell surface receptors with the capability of activating, through phosphorylation, multiple kinase cascades in response to activation by an extracellular ligand. ...
  • Regulation of Erythropoietin Receptor Endocytosis and Signaling 

    Sulahian, Rita (2009-01-14)
    Erythropoietin (Epo) and its receptor (EpoR) play an essential role in the survival, proliferation and differentiation of precursor red blood cells into mature erythrocytes. EpoR lacks intrinsic enzymatic activity essential ...