Now showing items 1-8 of 8

  • Apoptosis Determinants in Drosophila Melanogaster 

    Chew, Su Kit (2007-12-17)
    Apoptosis is a form of programmed cell death (PCD) that is governed by a core set of genes conserved across diverse metazoan phyla. Cells dying by apoptosis exhibit a characteristic series of morphological and biochemical ...
  • Bcl-2 Function in Drosophila 

    Galindo, Kathleen A. (2007-12-17)
    Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a ...
  • Biochemical Analysis of Apoptosome Formation 

    Kim, Hyun-Eui (2006-12-19)
    Apoptosis is an active cell death program executed by proteases named caspases. One of the major caspase-activating pathways is initiated by mitochondria. Upon various apoptotic stimuli, the mitochondria releases cytochrome ...
  • Communal Cell Death and P53 Mediated Transcriptional Control in Drosophila Melanogaster 

    Link, Nichole Lynn (2011-08-10)
    Apoptosis is essential for all metazoan development. The key component that functions in apoptosis, the apoptosome, is a molecular machine that initiates caspase activation and is conserved throughout the animal kingdom. ...
  • Genetic and Biochemical Analyses of the Necessity for Caspase Activation by the CED4-Domain Proteins, APAF-1 and DARK 

    Oliver, George Reinhold (2003-04-03)
    Activation of caspase proteases by Ced4 domain proteins is a critical step in the induction of programmed cell death, or apoptosis. Understanding of the genetic and biochemical regulation of the mammalian Ced-4 gene, Apaf-1, ...
  • Genetics of Stress-Induced Responses in Drosophila 

    Akdemir, Fatih (2006-08-11)
    Apoptosis is a highly conserved process responsible for elimination of cells during normal development and after cellular damage. Apical caspases that initiate caspase cascades are stimulated upon interaction with adaptor ...
  • Illuminating the P53 Regulatory Network in Genetic Models 

    Lu, Wan-Jin (2011-02-01)
    The tumor suppressor gene p53 is mutated in more than 50% of human cancers, and functions as a central component of stress response machinery that mediates a wide variety of downstream responses. Interestingly, the ...
  • p53 in a Genetic Model: Illuminating Adaptive Radiation Responses 

    Sogame, Naoko (2005-05-03)
    When cells are challenged by genotoxic stress, the tumor suppressor protein p53 promotes adaptive responses, including cell cycle arrest, DNA repair, or apoptosis. How these distinct fates are specified through an action ...