Browsing UT Southwestern Electronic Theses and Dissertations by Issue Date
Now showing items 21-40 of 948
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Regulation of Traffic into and out of the Yeast Endosome by the VPS9P Cue Domain and the VPS5P Domain
(2004-05-04)The presence of membrane bound compartments in eukaryotic cells enables the generation of discrete environments in which distinct and sometimes competing chemical reactions occur. The mammalian lysosome represents an example ... -
Mechanism and Regulation of ERK2 Subcellular Localization
(2004-05-04)Dynamic changes in the localization of activated proteins can be obligatory events in signaling networks that control cell behavior. ERK1/2 activation contributes to regulated processes such as proliferation, differentiation ... -
Uncovering the Complexity of RAS Signaling Networks
(2004-05-04)The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. ... -
Characterization of the FXYD Protein Family in the Regulation of Insulin Exocytosis
(2004-05-04)Insulin exocytosis is a complex, regulated process involving numerous exocytotic proteins to coordinate the release of insulin. Syncollin has been implicated in zymogen granule exocytosis in acinar cells. It was hypothesized ... -
Transcriptional Regulation of Cardiac Ventricular Development
(2004-05-04)Congenital heart disease is the leading non-infectious cause of death in children. Disruption of cardiac gene expression during development can result in congenital heart defects. Numerous transcription factors regulate ... -
Allosteric Determinants of Guanine Nucleotide Binding Proteins and Methods to Crystallize the Cytosolic Domains of Adenylyl Cyclase
(2004-05-04)The cytosolic domains of mammalian adenylyl cyclases, termed C1 and C2, are responsible for catalytic activity and most regulatory properties. Crystal structures of the soluble catalytic core of adenylyl cyclase bound to ... -
Identification and Characterization of a NEF-Associated Kinase
(2004-05-04)The nef gene encoded by primate lentiviruses is a major determinant of virulence in vivo. It is expressed early in the viral life cycle; its importance likely stems from its ability to prime the host environment for efficient ... -
Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
(2004-05-04)Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed ... -
To Develop a Small Interfering RNA (siRNA) Design and Information Resource to Facilitate Genetic Manipulaton of Human Cells
(2004-05-25)Part I: Small interfering RNAs (siRNAs) have revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdown of gene expression. In the ... -
Educating Health Care Professionals in the Threat of Biological Attacks: A Digital Guide to Smallpox
(2004-08-19)Following the terrorist attacks on September 11, 2001, and the Anthrax letters that followed shortly thereafter, the American government and public have had growing concerns over the possibility of biological and chemical ... -
Scaffold-Mediated Organization of Signal Transduction Networks
(2004-08-19)The Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to ... -
CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis
(2004-08-19)The Cdc14 family of protein phosphatases operate during the final stages of mitosis in various organisms. The Cdc14 phosphatases are downstream components of two homologous signaling pathways: the mitotic exit network (MEN) ... -
The Conserved Oligomeric Golgi (COG) Complex Is Required for Normal Import of Fatty Acids in Saccharomyces Cerevisiae
(2004-08-19)The goal of my work was to elucidate aspects of the mechanism of trafficking of membrane proteins to peroxisomes. The work described in this document centers around one protein from Saccharomyces cerevisiae, Cog7p. Cog7p ... -
Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
(2004-08-19)To avoid missegregation of chromosomes during mitosis cells employ a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase ... -
The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
(2004-08-19)A major goal of both feeding and drug abuse research is to understand the neural and molecular mechanisms that control intake and how dysfunction of these systems can lead to excessive food ingestion or addiction. Numerous ... -
Characterization of U2AF26, a Paralog of the Splicing Factor U2AF35
(2004-08-19)The essential splicing factor U2 auxiliary factor (U2AF) mediates 3' splice site recognition during spliceosome assembly. The mammalian U2AF is composed of a large subunit, U2AF65, and a small subunit, U2AF35. U2AF65 ... -
The Corticospinal and CorticobulbarTracts: An Animated Three-Dimensional Instructional Aid
(2004-08-19)The complex pathways of the neural tracts, from the cerebral cortex, through the complex anatomy of the brainstem, can be difficult for medical students to visualize and challenging for instructors to convey. Text references, ... -
Differences Between Individuals with Dissociative Identity Disorder (DID) Based on Receipt of Government Disability Benefits
(2004-08-19)This study compared outpatient individuals who have Dissociative Identity Disorder (DID) and receive governmental disability benefits (n=42) to individuals who have DID and are not receiving governmental disability benefits ... -
Examination of Abnormal Dolichol Metabolism in Infantile Batten Disease Caused by Palmitoyl Protein Thioesterase-1 (PPT1) Deficiency
(2004-08-19)The neuronal ceroid lipofuscinosis (NCLs, also known collectively as Batten disease) are a group of lysosomal storage disorders characterized by the accumulation of autofluorescent storage material in the brain. Although ... -
Peptide Nucleic Acid (PNA) Hybridization to Nucleic Acid Targets
(2004-12-15)Peptide nucleic acid (PNA) is a DNA/RNA mimic that offers many advantages for hybridization to nucleic acid targets. The simple premise of Watson- Crick base-pairing presents PNAs with a number of diverse applications ...