Congenital heart disease is the leading non-infectious cause of death in children. Disruption of cardiac gene expression during development can result in congenital heart defects. Numerous transcription factors regulate ...

The cytosolic domains of mammalian adenylyl cyclases, termed C1 and C2, are responsible for catalytic activity and most regulatory properties. Crystal structures of the soluble catalytic core of adenylyl cyclase bound to ...

The most common brain tumors originating in the cells of the brain are a family of tumors known as gliomas that are incurable and usually require some combination of surgery, radiation, and chemotherapy to manage tumor ...

The nef gene encoded by primate lentiviruses is a major determinant of virulence in vivo. It is expressed early in the viral life cycle; its importance likely stems from its ability to prime the host environment for efficient ...

This is the first detailed study of biofilm formation in vitro by the Gram-negative bacterial pathogen Moraxella catarrhalis. Growth of M. catarrhalis in a continuous-culture biofilm system resulted in little detectable ...

Following the terrorist attacks on September 11, 2001, and the Anthrax letters that followed shortly thereafter, the American government and public have had growing concerns over the possibility of biological and chemical ...

To avoid missegregation of chromosomes during mitosis cells employ a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase ...

The complex pathways of the neural tracts, from the cerebral cortex, through the complex anatomy of the brainstem, can be difficult for medical students to visualize and challenging for instructors to convey. Text references, ...

The goal of my work was to elucidate aspects of the mechanism of trafficking of membrane proteins to peroxisomes. The work described in this document centers around one protein from Saccharomyces cerevisiae, Cog7p. Cog7p ...

The Cdc14 family of protein phosphatases operate during the final stages of mitosis in various organisms. The Cdc14 phosphatases are downstream components of two homologous signaling pathways: the mitotic exit network (MEN) ...