Now showing items 1-6 of 6

  • Analysis of Aurora B Regulation and Signaling 

    Oncel, Dilhan (2006-05-16)
    Aurora B is a serine/threonine kinase that functions in a complex with two other chromosomal passenger proteins called INCENP and Survivin. Its function is implicated in a variety of processes related to mitosis, such as ...
  • CDK5RAP2 Regulates Centriole Licensing to Restrict Centriole Duplication in Mice 

    Barrera, Jose Anselmo (2009-09-04)
    Cells division is a highly coordinated series of events that must occur with extreme precision. Defects during segregation of genetic material (DNA) can have adverse effects on the health of the cell, surrounding tissue, ...
  • Centrosomin Self-Assembly and Centrosomal Protein Recruitment 

    Bauer, Ruth Anne (2005-08-11)
    Centrosomes, the major microtubule organizing centers in animal cells, are important for mitotic spindle formation. Normally, each cell has two centrosomes which migrate to opposite sides of the nuclear envelope prior to ...
  • Function And Recruitment Of Centromeric Heterochromatin Protein 1 

    Chaudhary, Jaideep (2011-02-01)
    During early mitosis, the sister chromatids are held together by Cohesin, a protein complex composed of Smc3, Smc1, Scc1/Rad21 and Scc3. Cohesin is first released from the arms of chromosomes, leaving it intact at the ...
  • Generating the Spindle Assembly Checkpoint Signal at the Kinetochore 

    Bharadwaj, Rajnish (2004-08-19)
    To avoid missegregation of chromosomes during mitosis cells employ a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase ...
  • The Mitotic Spindle Mediates Inheritance of the Golgi Ribbon Structures 

    Wei, Jen-Hsuan (2010-05-14)
    The mammalian Golgi ribbon disassembles during mitosis and reforms in both daughter cells after division. Mitotic Golgi membranes concentrate around the spindle poles, suggesting that the spindle may control Golgi partitioning. ...