Now showing items 1-4 of 4

  • Cotranslational Folding of CFTR 

    Patrick, Anna Elizabeth (2013-05)
    The life of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the cell is dictated by its biogenesis, cellular trafficking, regulated function, and destruction. Cystic fibrosis (CF) is the direct ...
  • Ion Selectivity and Gating in the NAK Channel 

    Alam, Amer (2009-06-15)
    Ion selectivity and gating are two fundamental properties central to proper physiological functioning of ion channels. In this work, a thorough structural characterization of ion binding profiles is presented for the NaK ...
  • Protein Structure and Ion Binding in Potassium Selective Channels 

    Sauer, David Bryant (2013-01-17)
    Potassium channels play a central role in a number of biological processes, most classically the action potential of excitable cells in multicellular organisms. These channels are defined by their selective conduction of ...
  • Structural Insights into Ion Selectivity and Calcium Blockage in Cyclic Nucleotide Gated Channels 

    Derebe, Mehabaw Getahun (2010-07-12)
    Cyclic nucleotides-gated (CNG) channels play an essential role in the visual and olfactory sensory systems and are ubiquitously expressed in a variety of neuronal and non neuronal cells. Details of their underlying ion ...