Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

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dc.contributor.advisor Kenneth M. Johnson, PhD. en_US
dc.creator Noelle Catherine Anastasio en_US
dc.date.accessioned 2011-12-20T16:04:59Z
dc.date.available 2008-06-17 en_US
dc.date.available 2011-12-20T16:04:59Z
dc.date.created 2005-07-20 en_US
dc.date.issued 2005-07-06 en_US
dc.identifier.other etd-07202005-145246 en_US
dc.identifier.uri http://hdl.handle.net/2152.3/170
dc.description.abstract Disruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor antagonists prior to acute or sub-chronic PCP. This study provides evidence that two distinct mechanisms underlie effects of acute and sub-chronic PCP on NMDA receptor subunit up-regulation. Furthermore, we discovered that D1, D2, and 5-HT2A receptors play a pivotal role in sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia. en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works. en_US
dc.subject schizophrenia en_US
dc.subject olanzapine en_US
dc.subject animal model en_US
dc.title Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development en_US
dc.type.material text en_US
dc.type.genre thesis en_US
thesis.degree.name Master of Science en_US
thesis.degree.level Master en_US
thesis.degree.grantor The University of Texas Medical Branch en_US
thesis.degree.department Pharmacology and Toxicology en_US
dc.contributor.committeeMember Kathryn Cunningham, PhD. en_US
dc.contributor.committeeMember Giulio Taglialatela, PhD. en_US
dc.contributor.committeeMember Geoffrey T. Swanson en_US

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