The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents

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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents

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dc.contributor.advisor Patricia Shinnick-Gallagher en_US
dc.creator Kady B. Schmidt en_US
dc.date.accessioned 2011-12-20T16:04:58Z
dc.date.available 2008-06-17 en_US
dc.date.available 2011-12-20T16:04:58Z
dc.date.created 2007-07-19 en_US
dc.date.issued 2007-07-17 en_US
dc.identifier.other etd-07192007-135057 en_US
dc.identifier.uri http://hdl.handle.net/2152.3/167
dc.description.abstract Currently, there are no approved medications for treating cocaine addiction, and cocaine addicts are highly prone to relapse. Cocaine cravings or seeking is difficult to control because of contextual cues and adequate treatment is not available. Previous studies found that group I metabotropic glutamate receptor (mGluR) antagonists can block the induction of conditioned place preference (CPP), a measure of cocaine seeking behavior, but their functions after clinically relevant withdrawal periods are not known. Our study showed that group I mGluR antagonists failed to block the expression of cocaine-induced CPP. Furthermore, the amygdala is known to be involved in the learned associations between cocaine and the cocaine-taking environment; changes in these associations are reflected in an in vitro model of plasticity, long-term potentiation, in amygdala pathways. Chronic cocaine withdrawal did not affect mGluR5-mediated LTP in the basolateral to central amygdala pathway. However, mGluR1-mediated LTP was reduced after cocaine administration and withdrawal and was partially due to GABA inhibition via endocannabinoids. en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works. en_US
dc.subject LTP en_US
dc.subject conditioned place preference en_US
dc.subject amygdala en_US
dc.title The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents en_US
dc.type.material text en_US
dc.type.genre thesis en_US
thesis.degree.name Master of Science en_US
thesis.degree.level Master en_US
thesis.degree.grantor The University of Texas Medical Branch en_US
thesis.degree.department Pharmacology and Toxicology en_US
dc.contributor.committeeMember Joseph C. Holt en_US
dc.contributor.committeeMember Joel P. Gallagher en_US

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