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dc.contributor.advisorPatricia Shinnick-Gallagheren_US
dc.creatorKady B. Schmidten_US
dc.date.accessioned2011-12-20T16:04:58Z
dc.date.available2008-06-17en_US
dc.date.available2011-12-20T16:04:58Z
dc.date.created2007-07-19en_US
dc.date.issued2007-07-17en_US
dc.identifier.otheretd-07192007-135057en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/167
dc.description.abstractCurrently, there are no approved medications for treating cocaine addiction, and cocaine addicts are highly prone to relapse. Cocaine cravings or seeking is difficult to control because of contextual cues and adequate treatment is not available. Previous studies found that group I metabotropic glutamate receptor (mGluR) antagonists can block the induction of conditioned place preference (CPP), a measure of cocaine seeking behavior, but their functions after clinically relevant withdrawal periods are not known. Our study showed that group I mGluR antagonists failed to block the expression of cocaine-induced CPP. Furthermore, the amygdala is known to be involved in the learned associations between cocaine and the cocaine-taking environment; changes in these associations are reflected in an in vitro model of plasticity, long-term potentiation, in amygdala pathways. Chronic cocaine withdrawal did not affect mGluR5-mediated LTP in the basolateral to central amygdala pathway. However, mGluR1-mediated LTP was reduced after cocaine administration and withdrawal and was partially due to GABA inhibition via endocannabinoids.en_US
dc.format.mediumelectronicen_US
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectLTPen_US
dc.subjectconditioned place preferenceen_US
dc.subjectamygdalaen_US
dc.titleThe role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodentsen_US
dc.type.materialtexten_US
dc.type.genrethesisen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelMasteren_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.departmentPharmacology and Toxicologyen_US
dc.contributor.committeeMemberJoseph C. Holten_US
dc.contributor.committeeMemberJoel P. Gallagheren_US


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