Ionic contributions to the oscillatory firing activity of rat cerebellar Purkinje cells

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Title: Ionic contributions to the oscillatory firing activity of rat cerebellar Purkinje cells
Author: Chang, Whasook Seo
Abstract: Intrinsic rhythmic firing patterns of neurons are believed to be mediated by sequential activation of a set of membrane ionic conductances . One of the most significant properties of oscillatory neurons in general is the presence of a negative slope resistance (NSR ) region in the steadystate , whole cell voltage clconp current -voltage relationship (I -V curve ) . Although it has been emphasized that rhythmic activity may form a basis for an intrinsic functional context of the cerebellum , ionic conductances involved in oscillatory activity in cerebellar Purkinje cells (PCs ) have yet to be fully determined . The major objective of this dissertation was to investigate the contribution of various conductances such as sodium (iNa ) / calcium (Ica ) / cationic inward (Ih ) / ^^d calcium -activated potassium (iR /ca ) )oscillatory activity of PCs .
URI: http : / /hdl .handle .net /2346 /18983
Date: 1993-05

Citation

Ionic contributions to the oscillatory firing activity of rat cerebellar Purkinje cells. Doctoral dissertation, Texas Tech University. Available electronically from http : / /hdl .handle .net /2346 /18983 .

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