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Abstract:
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The focus of my graduate research in the Krische group has been the development of catalytic carbon -carbon bond forming reactions with an emphasis on controlling diastereo - and enatio -selectivity in transfer hydrogenative couplings . The broad goal of our research program has been the development and implementation of efficient green methods for carbonyl addition employing [pi] -unsaturates as surrogates to preformed organometallic reagents , thus enabling byproduct free variants of traditional carbanion chemistry . This dissertation shows the new reactions that I have developed toward this goal . These reactions includes new metal catalyzed approaches for carbonyl crotylation , aminoallylation , and vinylogous reformatsky aldol reactions . |