| dc.contributor.advisor |
Nuñez , Nomelí P . |
|
| dc.contributor.committeeMember |
Hursting , Stephen D . |
|
| dc.creator |
Kushiro , Kyoko |
|
| dc.date.accessioned |
2012 -07 -18T20 :46 :44Z |
|
| dc.date.accessioned |
2012 -11 -29T20 :50 :16Z |
|
| dc.date.available |
2012 -07 -18T20 :46 :44Z |
|
| dc.date.available |
2012 -11 -29T20 :50 :16Z |
|
| dc.date.created |
2012 -05 |
|
| dc.date.issued |
2012 -07 -18 |
|
| dc.date.submitted |
May 2012 |
|
| dc.identifier.uri |
http : / /hdl .handle .net /2152 /ETD -UT -2012 -05 -4969 |
|
| dc.description.abstract |
Malignant melanoma is cancer arising from melanocytes that have acquired the ability to metastasize and colonize secondary organs such as the lungs , liver , and brain . According to the Melanoma Research Foundation , malignant melanoma is the most rapidly increasing type of cancer with an annual incidence increase of ~ 4 % despite the therapeutic and medical breakthroughs in cancer treatment . Melanoma is the most common cancer in young adults ages 20 -30 , and it is the leading cause of cancer death in females ages 25 -30 . Non -modifiable risk factors include age , gender , and inherited predisposition to moles . As for modifiable risk factors , exposure to UV rays from the sun is well -established , but obesity has recently emerged as a factor through recent epidemiological and animal studies . Our results showed that obesity modulates the expression of the transcription factor Snai1 , which has been shown to be a key gene in the regulation of the Epithelial -to -Mesenchymal Transition (EMT ) . Serum from obese
ob /ob mice , as well as conditioned media from 3T3L1 adipocytes , increased the invasive ability of melanoma cells and the expression of the transcription factor Snai1 . Yet , the cytokine IL -6 may not be a critical component of obesity -mediated B16BL6 melanoma cell invasiveness . |
|
| dc.format.mimetype |
application /pdf |
|
| dc.language.iso |
eng |
|
| dc.subject |
Obesity |
|
| dc.subject |
Melanoma |
|
| dc.subject |
Snai1 |
|
| dc.title |
Obesity promotes B16BL6 melanoma cell invasiveness and Snai1 expression |
|
| dc.description.department |
Cellular and Molecular Biology |
|
| dc.type.genre |
thesis |
* |
| dc.type.material |
text |
* |
| thesis.degree.name |
Master of Arts |
|
| thesis.degree.level |
Masters |
|
| thesis.degree.discipline |
Cell and Molecular Biology |
|
| thesis.degree.grantor |
University of Texas at Austin |
|
| thesis.degree.department |
Cellular and Molecular Biology |
|
| dc.date.updated |
2012 -07 -18T20 :46 :51Z |
|
| dc.identifier.slug |
2152 /ETD -UT -2012 -05 -4969 |
|