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Title:
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Developing a diagnostic tool for acyl carrier proteins through trypsinolysis, reverse-phase chromatography and native chemical ligation |
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Author:
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Reyes, Graciela, 1957- |
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Abstract:
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Polyketide biosynthesis is a field that has had tremendous advances in the past 50 years . The understanding of the mechanisms is updated as investigations delve into domain interactions of these microbial natural products . Although numerous polyketides are known , similarities in the sequence of product generation can be used as templates for further exploration of enzymatic activity . The focus of studies recently has been towards developing protocols to manipulate the natural products resulting in medicinally important manufactured products . This investigation examined the mechanism of the acyl carrier protein (ACP ) module involved in biosynthesis . |
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URI:
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http : / /hdl .handle .net /2152 /ETD -UT -2010 -08 -1725
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Date:
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2011-01-06 |