Transition metal catalyzed hydrogenative and transfer hydrogenative C-C bond formation

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Title: Transition metal catalyzed hydrogenative and transfer hydrogenative C-C bond formation
Author: Skucas, Eduardas
Abstract: Carbon -carbon bond formation is one the fundamental reactions in organic synthesis . The quest for the development of new and more efficient processes for the construction of this bond has been an ongoing focus for years . The transformations that permit the use of simple precursors to access complex structural architectures in the absence of stoichiometric quantities by -products are highly desirable . Hydrogen is a cheapest and cleanest reductant available to the mankind . The catalytic hydrogenation has been widely utilized in the industry , however the construction of the carbon -carbon bond under hydrogenative conditions has been achieved only for alkene hydroformylations and Fisher -Tropsh process and limited to the use of carbon monoxide . The extension of the hydrogenative carbon -carbon bond formations beyond aforementioned processes would be of a great significance to the synthetic community . The overview of allene use in the metal catalyzed reactions to achieve carbonyl and imine allylation and vinylation is presented in Chapter 1 . The following chapter vii discusses the development of metal catalyzed hydrogenative and transfer hydrogenative coupling of allenes and carbonyl compounds to afford allylation products . These studies have resulted in the development of the first carbonyl allylation from the alcohol oxidation level . Chapter 3 discusses efforts towards achieving highly enantioselective hydrogenative coupling of alkynes to carbonyl compounds .
URI: http : / /hdl .handle .net /2152 /ETD -UT -2009 -12 -444
Date: 2010-08-24

Citation

Transition metal catalyzed hydrogenative and transfer hydrogenative C-C bond formation. Doctoral dissertation, The University of Texas at Austin. Available electronically from http : / /hdl .handle .net /2152 /ETD -UT -2009 -12 -444 .

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