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Abstract:
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Carbon -carbon bond formation is one the fundamental reactions in organic
synthesis . The quest for the development of new and more efficient processes for the
construction of this bond has been an ongoing focus for years . The transformations that
permit the use of simple precursors to access complex structural architectures in the
absence of stoichiometric quantities by -products are highly desirable .
Hydrogen is a cheapest and cleanest reductant available to the mankind . The
catalytic hydrogenation has been widely utilized in the industry , however the construction
of the carbon -carbon bond under hydrogenative conditions has been achieved only for
alkene hydroformylations and Fisher -Tropsh process and limited to the use of carbon
monoxide . The extension of the hydrogenative carbon -carbon bond formations beyond
aforementioned processes would be of a great significance to the synthetic community .
The overview of allene use in the metal catalyzed reactions to achieve carbonyl
and imine allylation and vinylation is presented in Chapter 1 . The following chapter
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discusses the development of metal catalyzed hydrogenative and transfer hydrogenative
coupling of allenes and carbonyl compounds to afford allylation products . These studies
have resulted in the development of the first carbonyl allylation from the alcohol
oxidation level . Chapter 3 discusses efforts towards achieving highly enantioselective
hydrogenative coupling of alkynes to carbonyl compounds . |