Nanoimprint lithography based fabrication of size and shape-specific, enzymatically-triggered nanoparticles for drug delivery applications

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dc.contributor.advisor Roy , Krishnendu en_US
dc.contributor.advisor Shi , Li , Ph . D . en_US
dc.identifier.oclc 243480370 en_US
dc.creator Glangchai , Luz Cristal Sanchez , 1977 - en_US
dc.date.accessioned 2008 -08 -29T00 :17 :00Z
dc.date.accessioned 2014 -02 -19T22 :35 :37Z
dc.date.available 2008 -08 -29T00 :17 :00Z
dc.date.available 2014 -02 -19T22 :35 :37Z
dc.date.created 2008 -05 en_US
dc.date.issued 2008 -08 -29T00 :17 :00Z
dc.identifier.uri http : / /hdl .handle .net /2152 /3888
dc.description.abstract Our ability to precisely manipulate size , shape , and composition of nanoscale carriers is essential for controlling their in -vivo transport , biodistribution , and drug release mechanism . Shape -specific , "smart" nanoparticles that deliver drugs or imaging agents to target tissues primarily in response to disease -specific or physiological signals could significantly improve therapeutic care of complex diseases . Current methods in nanoparticle synthesis do not allow such simultaneous control over particle size , shape , and environmentally -triggered drug release , especially at the sub -100 nm range . In this dissertation , we discuss the development of high -throughput nanofabrication techniques using synthetic and biological macromers (peptides ) to produce highly monodisperse nanoparticles , as well as enzymatically -triggered nanoparticles , of precise sizes and shapes . We evaluated thermal nanoimprint lithography (ThNIL ) and step and flash imprint lithography (SFIL ) as two possible fabrication techniques . We successfully employed ThNIL and SFIL for fabricating nanoparticles and have extensively characterized the SFIL fabrication process , as well as the properties of the imprinted biopolymers . Particles as small as 50 nm were fabricated on silicon wafers and harvested directly into aqueous buffer using a biocompatible , one -step release technique . These methods provide a novel way to fabricate biocompatible nanoparticles with precise size and geometry . Furthermore , we developed an enzyme -degradable material system and demonstrated successful encapsulation and enzyme -triggered release of antibodies and nucleic acids from these imprinted nanoparticles ; thus providing a potential means for disease -controlled delivery of biomolecules . Finally , we evaluated the bioactivity of the encapsulated therapeutics in -vitro . The development of the SFIL method for fabrication of biocompatible nanocarriers has great potential in the drug delivery field for its ability to create monodisperse particles of pre -designed geometry and size , and to incorporate stimulus -responsive release mechanisms . This research provides the potential to broaden the study of how particle size and shape affect the biodistribution of drugs within the body . en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author . Presentation of this material on the Libraries' web site by University Libraries , The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works . en_US
dc.subject.lcsh Nanotechnology en_US
dc.subject.lcsh Nanoparticles en_US
dc.subject.lcsh Microlithography en_US
dc.subject.lcsh Drug delivery systems en_US
dc.subject.lcsh Peptides en_US
dc.title Nanoimprint lithography based fabrication of size and shape -specific , enzymatically -triggered nanoparticles for drug delivery applications en_US
dc.description.department Biomedical Engineering en_US
dc.identifier.recnum b70661030 en_US
dc.type.genre Thesis en_US
dc.type.material text en_US
thesis.degree.name Doctor of Philosophy en_US
thesis.degree.level Doctoral en_US
thesis.degree.discipline Biomedical Engineering en_US
thesis.degree.grantor The University of Texas at Austin en_US
thesis.degree.department Biomedical Engineering en_US

Citation

Nanoimprint lithography based fabrication of size and shape-specific, enzymatically-triggered nanoparticles for drug delivery applications. Doctoral dissertation, The University of Texas at Austin. Available electronically from http : / /hdl .handle .net /2152 /3888 .

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