Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor

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dc.contributor.advisor Avery , Leon en
dc.creator Yoshimoto , Jennifer Ann Winn en 2011 -12 -14T20 :19 :13Z en 2014 -02 -19T22 :03 :12Z 2011 -12 -14T20 :19 :13Z en 2014 -02 -19T22 :03 :12Z 2011 -12 -14 en
dc.identifier.other 769764372 en
dc.identifier.uri http : / /hdl .handle .net /2152 .5 /954 en
dc.description.abstract The development of an organism depends on cells receiving and executing their specific fates , though how this process is regulated remains largely unknown . Here , we identify a mechanism by which a specific cell fate , apoptosis , is determined through the cooperative efforts of Hox and E2F proteins . E2F transcription factors are critical , conserved regulators of the cell cycle and apoptosis . However , little is known about the two most recently discovered mammalian E2Fs— -E2F7 and E2F8 . In the nematode Caenorhabditis elegans , we identify a novel E2F7 /8 homolog , EFL -3 , and show that EFL -3 functions cooperatively with LIN -39 , providing the first example in which these two major developmental pathways— -E2F and Hox— -are able to directly regulate the same target gene . Our studies demonstrate that LIN -39 and EFL -3 function in a cell type -specific context to regulate transcription of the egl -1 BH3 only cell death gene and determine cell fate during development . en
dc.language.iso en en
dc.subject Caenorhabditis elegans en
dc.subject E2F Transcription Factors en
dc.subject Caenorhabditis elegans Proteins en
dc.title Identification and Characterization of EFL -3 , a C . Elegans E2F Transcription Factor en
dc.type Thesis en Doctor of Philosophy en Ph .D . en Genetics and Development en Graduate School of Biomedical Sciences en 2011 -12 -12 en


Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /954 .

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