Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure

Show simple item record


dc.contributor.advisor Lee , William M . en
dc.creator Gregory , Blake Elizabeth en
dc.date.accessioned 2011 -10 -03T13 :35 :34Z en
dc.date.accessioned 2014 -02 -19T22 :03 :04Z
dc.date.available 2011 -10 -03T13 :35 :34Z en
dc.date.available 2014 -02 -19T22 :03 :04Z
dc.date.issued 2011 -10 -03T13 :35 :34Z en
dc.identifier.other 760183830 en
dc.identifier.uri http : / /hdl .handle .net /2152 .5 /921 en
dc.description.abstract Acetaminophen is a dose -dependent toxin . Prognosis in severe acute liver injury is related presumably in part to the dose ingested . We sought to assess the value of acetaminophen dosing information in patients with acute liver failure due to acetaminophen toxicity to determine the role of dose as a prognostic indicator . Methods : Prospective data from 113 acute liver failure patients having single time point ingestions of acetaminophen were analyzed . Multivariate and chi -square tests were used to determine the relationship of dose to clinical outcome . We also used the Mann -Whitney U test to compare prognosis and survival in ALF with acetaminophen dose ingested . Results : Multivariate and chi -square analysis failed to show any relationship between acetaminophen dose and spontaneous survival . A separate analysis showed no correlation between acetaminophen dose and clinical prognostic indicators . Conclusions : Dose of acetaminophen ingested did not seem to play a role in prognosis . The most important prognostic factor was coma grade on admission to study . Acetaminophen dosing information is not always obtainable . When it is , it adds little to the clinical assessment . Severity of encephalopathy is a more reliable indicator of prognosis in these critically ill patients . Keywords : acetaminophen ; acute liver failure ; hepatology ; xose ; outcome ; survival ; toxicity en
dc.language.iso en en
dc.subject Acetaminophen en
dc.subject Liver Failure , Acute en
dc.subject Drug -Induced Liver Injury en
dc.title Acetaminophen Dose Does Not Predict Outcome in Acetaminophen -Induced Acute Liver Failure en
dc.type Dissertation en
thesis.degree.name Doctor of Medicine with Distinction in Research en
thesis.degree.level Ph .D . en
thesis.degree.grantor The University of Texas Southwestern Medical Center at Dallas en

Citation

Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure. The University of Texas Southwestern Medical Center at Dallas. Available electronically from http : / /hdl .handle .net /2152 .5 /921 .

Files in this item

Files Size Format View
GregoryBlake.pdf 325.9Kb application/pdf View/Open
GregoryBlake Abstract.docx 12.41Kb application/vnd.openxmlformats-officedocument.wordprocessingml.document View/Open

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse