Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure

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dc.contributor.advisor Lee , William M . en
dc.creator Gregory , Blake Elizabeth en 2011 -10 -03T13 :35 :34Z en 2014 -02 -19T22 :03 :04Z 2011 -10 -03T13 :35 :34Z en 2014 -02 -19T22 :03 :04Z 2011 -10 -03T13 :35 :34Z en
dc.identifier.other 760183830 en
dc.identifier.uri http : / /hdl .handle .net /2152 .5 /921 en
dc.description.abstract Acetaminophen is a dose -dependent toxin . Prognosis in severe acute liver injury is related presumably in part to the dose ingested . We sought to assess the value of acetaminophen dosing information in patients with acute liver failure due to acetaminophen toxicity to determine the role of dose as a prognostic indicator . Methods : Prospective data from 113 acute liver failure patients having single time point ingestions of acetaminophen were analyzed . Multivariate and chi -square tests were used to determine the relationship of dose to clinical outcome . We also used the Mann -Whitney U test to compare prognosis and survival in ALF with acetaminophen dose ingested . Results : Multivariate and chi -square analysis failed to show any relationship between acetaminophen dose and spontaneous survival . A separate analysis showed no correlation between acetaminophen dose and clinical prognostic indicators . Conclusions : Dose of acetaminophen ingested did not seem to play a role in prognosis . The most important prognostic factor was coma grade on admission to study . Acetaminophen dosing information is not always obtainable . When it is , it adds little to the clinical assessment . Severity of encephalopathy is a more reliable indicator of prognosis in these critically ill patients . Keywords : acetaminophen ; acute liver failure ; hepatology ; xose ; outcome ; survival ; toxicity en
dc.language.iso en en
dc.subject Acetaminophen en
dc.subject Liver Failure , Acute en
dc.subject Drug -Induced Liver Injury en
dc.title Acetaminophen Dose Does Not Predict Outcome in Acetaminophen -Induced Acute Liver Failure en
dc.type Dissertation en Doctor of Medicine with Distinction in Research en Ph .D . en The University of Texas Southwestern Medical Center at Dallas en


Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure. The University of Texas Southwestern Medical Center at Dallas. Available electronically from http : / /hdl .handle .net /2152 .5 /921 .

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