| dc.contributor |
Lee , William M . |
|
| dc.date |
2011 -10 -03T13 :35 :34Z |
|
| dc.date |
2011 -10 -03T13 :35 :34Z |
|
| dc.date |
2011 -10 -03T13 :35 :34Z |
|
| dc.date.accessioned |
2013 -04 -17T19 :03 :52Z |
|
| dc.date.available |
2013 -04 -17T19 :03 :52Z |
|
| dc.date.issued |
2013 -04 -17 |
|
| dc.identifier |
760183830 |
|
| dc.identifier |
http : / /hdl .handle .net /2152 .5 /921 |
|
| dc.identifier.uri |
http : / /hdl .handle .net /2152 .5 /921 |
|
| dc.description |
Acetaminophen is a dose -dependent toxin . Prognosis in severe acute liver injury is related presumably in part to the dose ingested . We sought to assess the value of acetaminophen dosing information in patients with acute liver failure due to acetaminophen toxicity to determine the role of dose as a prognostic indicator . Methods : Prospective data from 113 acute liver failure patients having single time point ingestions of acetaminophen were analyzed . Multivariate and chi -square tests were used to determine the relationship of dose to clinical outcome . We also used the Mann -Whitney U test to compare prognosis and survival in ALF with acetaminophen dose ingested . Results : Multivariate and chi -square analysis failed to show any relationship between acetaminophen dose and spontaneous survival . A separate analysis showed no correlation between acetaminophen dose and clinical prognostic indicators . Conclusions : Dose of acetaminophen ingested did not seem to play a role in prognosis . The most important prognostic factor was coma grade on admission to study . Acetaminophen dosing information is not always obtainable . When it is , it adds little to the clinical assessment . Severity of encephalopathy is a more reliable indicator of prognosis in these critically ill patients .
Keywords : acetaminophen ; acute liver failure ; hepatology ; xose ; outcome ; survival ; toxicity |
|
| dc.language |
en |
|
| dc.subject |
Acetaminophen |
|
| dc.subject |
Liver Failure , Acute |
|
| dc.subject |
Drug -Induced Liver Injury |
|
| dc.title |
Acetaminophen Dose Does Not Predict Outcome in Acetaminophen -Induced Acute Liver Failure |
|
| dc.type |
Dissertation |
|