Characterization and Differences Between Possible and Probable Mild Cognitive Impairment

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Title: Characterization and Differences Between Possible and Probable Mild Cognitive Impairment
Author: Denney, David Austin
Abstract: Mild Cognitive Impairment (MCI ) is the period of subtle cognitive decline that occurs between normal aging and clinical Alzheimer's Disease (AD ) . Patients' subjective memory complaints (SMCs ) are essential to the diagnosis of MCI . In cases where memory complaints are not verifiable by objective measures , patients are left without a formal diagnosis of cognitive impairment . The current proposal describes a study designed to compare the cognitive features and risk factors of AD in subgroups of patients with SMCs with (Probable MCI ) and without (Possible MCI ) objective memory deficits in relation to controls . It is predicted that the Probable MCI group will demonstrate lower performance and have a greater decline on neuropsychological measures than patients diagnosed with Possible MCI , who will demonstrate lower performance and have a greater decline on those measures than controls . Also , it is predicted that Probable MCI patients will have greater incidence of vascular risk factors and presence of the apolipoprotein element 4 (APOE -4 ) allele than the Possible MCI patients , who will have higher incidence of these variables than controls . There is also a demographic analysis designed to identify any differences in age , education , and gender between the groups . Implications of possible outcomes of the study are then discussed .
URI: http : / /hdl .handle .net /2152 .5 /747
Date: 2009-06-15

Citation

Characterization and Differences Between Possible and Probable Mild Cognitive Impairment. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /747 .

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