|
Description:
|
The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood . The process of adult neurogenesis is well -described , but the source of proliferating progenitors is unknown . One potential source is the Type -1 cell , which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin . However , there is no direct evidence that Type -1 cells are the source of neurogenesis . For this doctoral research , I asked two questions to gain more insight into the role of Type -1 cells in adult The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood . The process of adult neurogenesis is well -described , but the source of proliferating progenitors is unknown . One potential source is the Type -1 cell , which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin . However , there is no direct evidence that Type -1 cells are the source of neurogenesis . For this doctoral research , I asked two questions to gain more insight into the role of Type -1 cells in adult GL -YFP but not Nes -YFP mice showed recovery of YFP+ progenitors , suggesting that GL -YFP cells are stem -like while Nes -YFP cells are progenitor -like . This correlative and causative evidence that nestin -expressing Type -1 cells are not the source of neurogenesis significantly advances our understanding of the neurogenic process . |