Exploring a Functional Disconnect Between Nestin-Expressing Type-1 Cells and Adult Hippocampal Neurogenesis

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Title: Exploring a Functional Disconnect Between Nestin-Expressing Type-1 Cells and Adult Hippocampal Neurogenesis
Author: DeCarolis, Nathan Anthony
Abstract: The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood . The process of adult neurogenesis is well -described , but the source of proliferating progenitors is unknown . One potential source is the Type -1 cell , which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin . However , there is no direct evidence that Type -1 cells are the source of neurogenesis . For this doctoral research , I asked two questions to gain more insight into the role of Type -1 cells in adult The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood . The process of adult neurogenesis is well -described , but the source of proliferating progenitors is unknown . One potential source is the Type -1 cell , which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin . However , there is no direct evidence that Type -1 cells are the source of neurogenesis . For this doctoral research , I asked two questions to gain more insight into the role of Type -1 cells in adult GL -YFP but not Nes -YFP mice showed recovery of YFP+ progenitors , suggesting that GL -YFP cells are stem -like while Nes -YFP cells are progenitor -like . This correlative and causative evidence that nestin -expressing Type -1 cells are not the source of neurogenesis significantly advances our understanding of the neurogenic process .
URI: http : / /hdl .handle .net /2152 .5 /718
Date: 2010-05-14

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Exploring a Functional Disconnect Between Nestin-Expressing Type-1 Cells and Adult Hippocampal Neurogenesis. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /718 .

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