BTB-Kelch Proteins and TAk1 Kinase N Immune Function

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Title: BTB-Kelch Proteins and TAk1 Kinase N Immune Function
Author: Liu, Hong-Hsing
Abstract: BTB -kelch proteins are putative components of E3 ligases with a BTB domain at the N terminus and several kelch repeats at the C terminus . KLHL6 and mKELCH are two members of this family . Conditional ablation of Klhl6 in B cells resulted in mild developmental phenotypes in bone marrow precursors . The number of peripheral B cells was decreased by half , and responded defectively in germinal center formation after antigen stimulations . mKELCH is a novel protein cloned from hearts . Knocked -in LacZ expressed predominantly at muscles and several photosensitive organs . TAK1 is a member of MAPKKK . Deletion of TAK1 prevented the maturation of CD4+ or CD8+ single positive thymocytes , leading to reduction of T cells in peripheral tissues . Thymocytes lacking TAK1 failed to activate NF -κB and JNK , and were prone to apoptosis upon stimulation . All three mouse models have provided important evidences in elucidating biological functions for each protein in vivo .
URI: http : / /hdl .handle .net /2152 .5 /414
Date: 2006-12-19

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BTB-Kelch Proteins and TAk1 Kinase N Immune Function. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /414 .

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