UCHLI in the Mammalian Nervous System

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dc.contributor.advisor Lin , Weichun en
dc.creator Myers , Kalisa Galina en
dc.date.accessioned 2010 -07 -12T17 :55 :58Z en
dc.date.accessioned 2014 -02 -19T22 :01 :44Z
dc.date.available 2010 -07 -12T17 :55 :58Z en
dc.date.available 2014 -02 -19T22 :01 :44Z
dc.date.issued 2008 -9 -18 en
dc.identifier.other en
dc.identifier.uri http : / /hdl .handle .net /2152 .5 /403 en
dc.description.abstract UCHL1 , or Ubiquitin Carboxy Terminal Hydrolase L1 , is a de -ubiquitinating enzyme (DUB ) thought to be involved in ubiquitin recycling . Beyond this , its natural function is almost wholly unknown . Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype . Using one of these mouse models , in which a lacz -neo construct is cloned in under the UCHL1 promoter , we have studied the gross progression of phenotype of these mice , characterized the expression pattern of UCHLO1 in brain , spinal cord , and lumbar dorsal root ganglia , described degeneration of muscle spindles , and established a timecourse of degeneration of neuromuscular junctions . Presented in this thesis is the culmination of these studies . en
dc.format.medium Electronic en
dc.format.mimetype application /pdf en
dc.language.iso en en
dc.subject Ubiquitin Thiolesterase en
dc.subject Central Nervous System en
dc.subject Nerve Degeneration en
dc.title UCHLI in the Mammalian Nervous System en
dc.type.genre dissertation en
dc.type.material Text en
thesis.degree.name Master of Science en
thesis.degree.level M .S . en
thesis.degree.discipline Neuroscience en
thesis.degree.grantor Graduate School of Biomedical Sciences en
thesis.degree.department en
dc.format.digitalOrigin born digital en
thesis.date.available 2009 -09 -18 en

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UCHLI in the Mammalian Nervous System. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /403 .

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