UCHLI in the Mammalian Nervous System

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Title: UCHLI in the Mammalian Nervous System
Author: Myers, Kalisa Galina
Abstract: UCHL1 , or Ubiquitin Carboxy Terminal Hydrolase L1 , is a de -ubiquitinating enzyme (DUB ) thought to be involved in ubiquitin recycling . Beyond this , its natural function is almost wholly unknown . Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype . Using one of these mouse models , in which a lacz -neo construct is cloned in under the UCHL1 promoter , we have studied the gross progression of phenotype of these mice , characterized the expression pattern of UCHLO1 in brain , spinal cord , and lumbar dorsal root ganglia , described degeneration of muscle spindles , and established a timecourse of degeneration of neuromuscular junctions . Presented in this thesis is the culmination of these studies .
URI: http : / /hdl .handle .net /2152 .5 /403
Date: 2008-9-18


UCHLI in the Mammalian Nervous System. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /403 .

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