Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis

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dc.contributor.advisor Niederkorn , Jerry en
dc.creator Hurt , Michael Allen en
dc.date.accessioned 2010 -07 -12T17 :32 :30Z en
dc.date.accessioned 2014 -02 -19T22 :01 :18Z
dc.date.available 2010 -07 -12T17 :32 :30Z en
dc.date.available 2014 -02 -19T22 :01 :18Z
dc.date.issued 2004 -01 -14 en
dc.identifier.other en
dc.identifier.uri http : / /hdl .handle .net /2152 .5 /312 en
dc.description.abstract Acanthamoeba spp . are ubiquitously distributed in the environment . The trophozoite form can infect the cornea and cause sight -threatening corneal inflammation known as Acanthamoeba keratitis . The pathogenic cascade of Acanthamoeba keratitis begins when Acanthamoebae bind to mannose expressed on traumatized corneas . Published reports indicate that mannose is upregulated on the corneal surface during wound healing . Experiments in laboratory animals have shown that corneal abrasion prior to infection is essential for generating Acanthamoeba keratitis . Furthermore , supernatants from Acanthamoeba en
dc.format.medium Electronic en
dc.format.mimetype application /pdf en
dc.language.iso en en
dc.subject Eye Infections , Parasitic en
dc.subject Acanthamoeba Keratitis en
dc.subject Protozoan Proteins en
dc.title Acanthamoeba spp . Secrete a Mannose -induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis en
dc.type.genre dissertation en
dc.type.material Text en
thesis.degree.name Doctor of Philosophy en
thesis.degree.level Ph .D . en
thesis.degree.discipline en
thesis.degree.grantor Graduate School of Biomedical Sciences en
thesis.degree.department en
dc.format.digitalOrigin born digital en
thesis.date.available 2005 -01 -14 en

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Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /312 .

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