Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis

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Title: Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis
Author: Hurt, Michael Allen
Abstract: Acanthamoeba spp . are ubiquitously distributed in the environment . The trophozoite form can infect the cornea and cause sight -threatening corneal inflammation known as Acanthamoeba keratitis . The pathogenic cascade of Acanthamoeba keratitis begins when Acanthamoebae bind to mannose expressed on traumatized corneas . Published reports indicate that mannose is upregulated on the corneal surface during wound healing . Experiments in laboratory animals have shown that corneal abrasion prior to infection is essential for generating Acanthamoeba keratitis . Furthermore , supernatants from Acanthamoeba
URI: http : / /hdl .handle .net /2152 .5 /312
Date: 2004-01-14

Citation

Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis. Graduate School of Biomedical Sciences. Available electronically from http : / /hdl .handle .net /2152 .5 /312 .

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