Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference

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dc.contributor.advisor Patricia Shinnick -Gallagher , Ph .D . en_US
dc.contributor.committeeMember Joseph Holt , Ph .D . en_US
dc.contributor.committeeMember Golda Anne Kevetter -Leonard , Ph .D . en_US
dc.creator Kathy Marie Genzer en_US
dc.date.accessioned 2011 -12 -20T16 :05 :44Z
dc.date.accessioned 2014 -02 -19T22 :05 :50Z
dc.date.available 2010 -09 -28 en_US
dc.date.available 2011 -12 -20T16 :05 :44Z
dc.date.available 2014 -02 -19T22 :05 :50Z
dc.date.created 2008 -12 -16 en_US
dc.date.issued 2008 -11 -24 en_US
dc.identifier.other etd -12162008 -112804 en_US
dc.identifier.uri http : / /hdl .handle .net /2152 .3 /295
dc.description.abstract One of the biggest problems facing cocaine addicts is relapse and currently there are no treatments for relapse . These studies will provide insight into the underlying mechanisms of LTP mediating relapse to cocaine . A major mechanism of cocaine in addiction is to inhibit dopamine re -uptake and glutamate is an excitatory neurotransmitter involved in addiction . Previous studies have demonstrated a link between phospholipase D (PLD ) and metabotropic glutamate receptors (mGluRs ) , while other studies show an interaction between dopamine receptors (DRs ) and PLD . Therefore , we investigated the mechanisms of the dopamine agonist -induced synaptic plasticity that is enhanced in the amygdala due to cocaine exposure in the Central -Basolateral Amygdala (CeA -BLA ) pathway . Electrophysiology recordings showed that the dopamine agonist -induced LTP is mediated via D1 receptors and is dependent upon mGluR1 and the mGluR linked to PLD and partially dependent upon mGluR5 and phospholipase C (PLC ) . Western blots and co -immunoprecipitations revealed increased expression of PLD after cocaine administration and possible physical interactions between group I mGluRs and PLD and DRs and PLD . PLD activity assays showed that PLD activity was decreased by antagonists of mGluR1 and the mGluR linked to PLD and was increased by the agonist for the mGluR linked to PLD . Basal PLD activity may also be mediated by D1 receptors and was not affected by mGluR5 antagonists . en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author . Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works . en_US
dc.subject PLD en_US
dc.subject dopamine en_US
dc.subject cocaine addiction en_US
dc.subject amygdala en_US
dc.title Dopamine -induced synaptic plasticity in the amygdala in saline -and cocaine -treated animals undergoing conditioned place preference en_US
dc.type.genre thesis en_US
dc.type.material text en_US
thesis.degree.name Master of Science en_US
thesis.degree.level Master en_US
thesis.degree.grantor The University of Texas Medical Branch en_US
thesis.degree.department Pharmacology and Toxicology en_US

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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference. The University of Texas Medical Branch. Available electronically from http : / /hdl .handle .net /2152 .3 /295 .

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