Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury

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dc.contributor.committeeMember Wolfgang Maret , Ph .D . en_US
dc.contributor.committeeMember Kelly Dineley , Ph .D . en_US
dc.contributor.committeeMember Helen Hellmich , Ph .D . en_US
dc.contributor.committeeMember Claudia Robertson , M .D . en_US
dc.creator Bridget Eva Hawkins en_US
dc.date.accessioned 2011 -12 -20T16 :05 :35Z
dc.date.accessioned 2014 -02 -19T22 :05 :42Z
dc.date.available 2008 -12 -10 en_US
dc.date.available 2011 -12 -20T16 :05 :35Z
dc.date.available 2014 -02 -19T22 :05 :42Z
dc.date.created 2008 -11 -19 en_US
dc.date.issued 2008 -07 -15 en_US
dc.identifier.other etd -11192008 -142130 en_US
dc.identifier.uri http : / /hdl .handle .net /2152 .3 /266
dc.description.abstract Traumatic brain injury (TBI ) is a leading cause of morbidity and mortality of Americans both in the 15 -25 age range and in the elderly population . Hippocampal neuronal damage is a key feature of experimental fluid percussion traumatic brain injury in rodents . However , the mechanisms contributing to the susceptibility to neuronal injury in this region are largely unknown . Since free ionic zinc (Zn2+ ) was shown to be toxic to neurons in vitro , I sought to examine the effects of Zn2+ on neuronal injury following TBI . To study this problem , I characterized a model of Zn2+ -induced injury in an attempt to isolate zinc’s effect on cell death , in vivo . I also adapted a fluorimetric method to measure the amount of extracellular Zn2+ present following TBI , using microdialysis techniques . To date , the measurement of free ionic Zn2+ release in vivo after trauma has not been shown . I demonstrate that the amount of Zn2+ found in the extracellular fluid of TBI rats was below the range that causes neuronal injury and was not different than the amount of Zn2+ found in sham operated rats . Results of my experiments do not support the idea that presynaptic release of Zn2+ causes injury to surrounding neurons . en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author . Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works . en_US
dc.subject zinc en_US
dc.subject traumatic brain injury en_US
dc.subject neurotoxicity en_US
dc.subject fluid percussion injury en_US
dc.title Zinc -mediated cell death in the hippocampus following experimental traumatic brain injury en_US
dc.type.genre dissertation en_US
dc.type.material text en_US
thesis.degree.name PhD en_US
thesis.degree.level Doctoral en_US
thesis.degree.grantor The University of Texas Medical Branch en_US
thesis.degree.department Neuroscience en_US

Citation

Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury. Doctoral dissertation, The University of Texas Medical Branch. Available electronically from http : / /hdl .handle .net /2152 .3 /266 .

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