Buprenorphine metabolism by preterm placentas: A pilot study

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dc.contributor.advisor Irina Pikuleva en_US
dc.contributor.committeeMember Patricia Shinnick -Gallagher en_US
dc.contributor.committeeMember Mary Treinen -Moslen en_US
dc.contributor.committeeMember Kenneth M . Johnson en_US
dc.creator Rachel McRee Kaufman en_US
dc.date.accessioned 2011 -12 -20T16 :05 :31Z
dc.date.accessioned 2014 -02 -19T22 :05 :40Z
dc.date.available 2008 -06 -17 en_US
dc.date.available 2011 -12 -20T16 :05 :31Z
dc.date.available 2014 -02 -19T22 :05 :40Z
dc.date.created 2007 -11 -14 en_US
dc.date.issued 2007 -10 -31 en_US
dc.identifier.other etd -11142007 -200615 en_US
dc.identifier.uri http : / /hdl .handle .net /2152 .3 /254
dc.description.abstract The focus of this investigation is to attempt to identify and characterize the major enzyme responsible for metabolism of buprenorphine to nor -buprenorphine in human preterm placentas and to elucidate whether the development /gestational age of the placenta affects metabolism of buprenorphine . The estimated apparent Km did not appear to change with gestational age suggesting the affinity of buprenorphine does not change throughout gestation . On the other hand , the estimated Vmax did appear to increase with gestational age suggesting the activity increases with gestational age . Our attempt to identify the enzyme responsible for metabolism in earlier gestational age placentas revealed that CYP19 remains the major metabolizing enzyme of buprenorphine but suggests additional enzymes may be involved , namely , CYP3A4 , 1A1 , 2E1 , 2D6 and 2C19 . Further studies must be conducted for conclusions to be drawn but we hope this report can contribute to the design of future studies on preterm placental metabolism of drugs . en_US
dc.format.medium electronic en_US
dc.language.iso eng en_US
dc.rights Copyright © is held by the author . Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works . en_US
dc.subject pregnancy en_US
dc.subject human placental aromatase / CYP19 en_US
dc.subject buprenorphine en_US
dc.title Buprenorphine metabolism by preterm placentas : A pilot study en_US
dc.type.genre thesis en_US
dc.type.material text en_US
thesis.degree.name Master of Science en_US
thesis.degree.level Master en_US
thesis.degree.grantor The University of Texas Medical Branch en_US
thesis.degree.department Pharmacology and Toxicology en_US

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Buprenorphine metabolism by preterm placentas: A pilot study. The University of Texas Medical Branch. Available electronically from http : / /hdl .handle .net /2152 .3 /254 .

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