Synthesis of gold nano-particles in a microfluidic platform for water quality monitoring applications

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Title: Synthesis of gold nano-particles in a microfluidic platform for water quality monitoring applications
Author: Datta, Sayak
Abstract: A microfluidic lab -on -a -chip (LOC ) device for in -situ synthesis of gold nano -particles was developed . The long term goal is to develop a portable hand -held diagnostic platform for monitoring water quality (e .g . , detecting metal ion pollutants ) . The LOC consists of micro -chambers housing different reagents and samples that feed to a common reaction chamber . The reaction products are delivered to several waste chambers in a pre -defined sequence to enable reagents / samples to flow into and out of the reaction chamber . Passive flow actuation is obtained by capillary driven flow (wicking ) and dissolvable microstructures called ?salt pillars ? . The LOC does not require any external power source for actuation and the passive microvalves enable flow actuation at predefined intervals . The LOC and the dissolvable microstructures are fabricated using a combination of photolithography and soft lithography techniques . Experiments were conducted to demonstrate the variation in the valve actuation time with respect to valve position and geometric parameters . Subsequently , analytical models were developed using one dimensional linear diffusion theory . The analytical models were in good agreement with the experimental data . The microvalves were developed using various salts : polyethylene glycol , sodium chloride and sodium acetate . Synthesized in -situ in our experiments , gold nano -particles exhibit specific colorimetric and optical properties due to the surface plasmon resonance effect . These stabilized mono -disperse gold nano -particles can be coated with bio -molecular recognition motifs on their surfaces . A colorimetric peptide assay was thus developed using the intrinsic property of noble metal nano -particles . The LOC device was further developed on a paper microfluidics platform . This platform was tested successfully for synthesis of gold nano -particles using a peptide assay and using passive salt -bridge microvalves . This study proves the feasibility of a LOC device that utilizes peptide assay for synthesis of gold nano -particles in -situ . It could be highly significant in a simple portable water quality monitoring platform .
URI: http : / /hdl .handle .net /1969 .1 /ETD -TAMU -3189
Date: 2009-05-15

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Synthesis of gold nano-particles in a microfluidic platform for water quality monitoring applications. Available electronically from http : / /hdl .handle .net /1969 .1 /ETD -TAMU -3189 .

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