Systems Medicine: An Integrated Approach with Decision Making Perspective

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Title: Systems Medicine: An Integrated Approach with Decision Making Perspective
Author: Faryabi, Babak
Abstract: Two models are proposed to describe interactions among genes , transcription factors , and signaling cascades involved in regulating a cellular sub -system . These models fall within the class of Markovian regulatory networks , and can accommodate for different biological time scales . These regulatory networks are used to study pathological cellular dynamics and discover treatments that beneficially alter those dynamics . The salient translational goal is to design effective therapeutic actions that desirably modify a pathological cellular behavior via external treatments that vary the expressions of targeted genes . The objective of therapeutic actions is to reduce the likelihood of the pathological phenotypes related to a disease . The task of finding effective treatments is formulated as sequential decision making processes that discriminate the gene -expression profiles with high pathological competence versus those with low pathological competence . Thereby , the proposed computational frameworks provide tools that facilitate the discovery of effective drug targets and the design of potent therapeutic actions on them . Each of the proposed system -based therapeutic methods in this dissertation is motivated by practical and analytical considerations . First , it is determined how asynchronous regulatory models can be used as a tool to search for effective therapeutic interventions . Then , a constrained intervention method is introduced to incorporate the side -effects of treatments while searching for a sequence of potent therapeutic actions . Lastly , to bypass the impediment of model inference and to mitigate the numerical challenges of exhaustive search algorithms , a heuristic method is proposed for designing system -based therapies . The presentation of the key ideas in method is facilitated with the help of several case studies .
URI: http : / /hdl .handle .net /1969 .1 /ETD -TAMU -2009 -08 -2940
Date: 2010-01-14


Systems Medicine: An Integrated Approach with Decision Making Perspective. Available electronically from http : / /hdl .handle .net /1969 .1 /ETD -TAMU -2009 -08 -2940 .

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