Educational attainment and rate of cognitive decline in Alzheimer's disease

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Title: Educational attainment and rate of cognitive decline in Alzheimer's disease
Author: Hemmy, Laura Sue
Abstract: Alzheimer ?s disease (AD ) progression and hypotheses of the cognitive reserve theory were investigated by testing for a relation between educational attainment and rate of decline in patients with Mild Cognitive Impairment , possible AD , probable AD , and other progressive neurodegenerative dementias . Patient data (n = 726 ) were acquired from a clinical database at the Minneapolis VAMC GRECC Memory Loss Clinic . Analyses using mixed effect regression models found education was significantly related to an accelerated rate of decline in global cognition (MMSE : -0 .022 , SE = 0 .007 , p = .003 ) and a steeper linear rate of decline in functional ability (Cognitive Performance Test : -0 .034 , SE = 0 .011 , p = .005 ) . Cox proportional hazard models found little evidence to support an association between educational attainment and relative mortality risk . These results are consistent with previous findings and predictions of the cognitive reserve theory .
URI: http : / /hdl .handle .net /1969 .1 /ETD -TAMU -1189
Date: 2009-05-15

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Educational attainment and rate of cognitive decline in Alzheimer's disease. Available electronically from http : / /hdl .handle .net /1969 .1 /ETD -TAMU -1189 .

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