In vivo blood oxygenation level measurements using photoacoustic microscopy

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Title: In vivo blood oxygenation level measurements using photoacoustic microscopy
Author: Sivaramakrishnan, Mathangi
Abstract: We investigate the possibility of extracting accurate functional information such as local blood oxygenation level using multi -wavelength photoacoustic measurements . Photoacoustic microscope is utilized to acquire images of microvasculature in smallanimal skin . Owing to endogenous optical contrast , optical spectral information obtained from spectral photoacoustic measurements are successfully inverted to yield oxygenation level in blood . Analysis of error propagation from photoacoustic measurements to inverted quantities showed minimum inversion error in the optical wavelength region of 570 -600 nm . To obtain accurate and vessel size independent blood oxygenation measurements , transducers with central frequency of more than 25 MHz are needed for the optical region of 570 -600 nm used in this study . The effect of transducer focal position on accuracy of blood oxygenation level quantification was found to be negligible . To obtain accurate measurements in vivo , one needs to compensate for factors such as spectral dependent optical attenuation .
URI: http : / /hdl .handle .net /1969 .1 /5851
Date: 2007-09-17

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In vivo blood oxygenation level measurements using photoacoustic microscopy. Available electronically from http : / /hdl .handle .net /1969 .1 /5851 .

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