142pr glass seeds for the brachytherapy of prostate cancer

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Title: 142pr glass seeds for the brachytherapy of prostate cancer
Author: Jung, Jae Won
Abstract: A beta -emitting glass seed was proposed for the brachytherapy treatment of prostate cancer . Criteria for seed design were derived and several beta -emitting nuclides were examined for suitability . 142Pr was selected as the isotope of choice . Seeds 0 .08 cm in diameter and 0 .9 cm long were manufactured for testing . The seeds were activated in the Texas A &M University research reactor . The activity produced was as expected when considering the meta -stable state and epi -thermal neutron flux . The MCNP5 Monte Carlo code was used to calculate the quantitative dosimetric parameters suggested in the American Association of Physicists in Medicine (AAPM ) TG -43 /60 . The Monte Carlo calculation results were compared with those from a dose point kernel code . The dose profiles agree well with each other . The gamma dose of 142Pr was evaluated . The gamma dose is 0 .3 Gy at 1 .0 cm with initial activity of 5 .95 mCi and is insignificant to other organs . Measurements were performed to assess the 2 -dimensional axial dose distributions using Gafchromic radiochromic film . The radiochromic film was calibrated using an X -ray machine calibrated against a National Institute of Standards and Technology (NIST ) traceable ion chamber . A calibration curve was derived using a least squares fit of a second order polynomial . The measured dose distribution agrees well with results from the Monte Carlo simulation . The dose was 130 .8 Gy at 6 mm from the seed center with initial activity of 5 .95 mCi . AAPM TG -43 /60 parameters were determined . The reference dose rate for 2 mm and 6 mm were 0 .67 and 0 .02 cGy /s /mCi , respectively . The geometry function , radial dose function and anisotropy function were generated .
URI: http : / /hdl .handle .net /1969 .1 /5738
Date: 2007-09-17

Citation

142pr glass seeds for the brachytherapy of prostate cancer. Available electronically from http : / /hdl .handle .net /1969 .1 /5738 .

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