Abnormal reproductive function in female homozygous leaner mice

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dc.contributor.advisor Abbott , Louise C . en_US
dc.contributor.committeeMember McArthur , Newell en_US
dc.creator Serpedin , Nesrin en_US
dc.date.accessioned 2004 -09 -30T02 :11 :20Z
dc.date.accessioned 2014 -02 -19T18 :31 :26Z
dc.date.available 2004 -09 -30T02 :11 :20Z
dc.date.available 2014 -02 -19T18 :31 :26Z
dc.date.created 2003 -12 en_US
dc.date.issued 2004 -09 -30T02 :11 :20Z
dc.identifier.uri http : / /hdl .handle .net /1969 .1 /559
dc.description.abstract The leaner mouse carries an autosomal recessive mutation in the ?1A subunit of neuronal P /Q -type voltage gated calcium ion channels . Due to this mutation , the leaner mouse exhibits severe ataxia , absence seizures and paroxysmal dyskinesia . Mutations in this same gene in humans cause : episodic ataxia type 2 , familial hemiplegic migraine , spinocerebellar ataxia type 6 and probably the newly recognized form of human inherited epilepsy . Decreased amplitude of calcium current in cerebellar Purkinje cells and decreased calcium buffering capacity suggest that failure of calcium homeostasis may lead to the neurodegeneration observed in these mutant mice . Both sexes are affected . Despite their neurological dysfunction , homozygous leaner mice are able to breed and produce viable offspring . The survival rate for these pups is highly correlated with early fostering to normal lactating dams . This thesis studies the reproductive dysfunction observed in female homozygous leaner mice and is divided into four parts : onset of puberty , estrous cycle , pregnancy and litter assessment , and hormone levels . We have discovered that the onset of puberty is precocious in leaner females compared to age -matched wild type females , and leaner mice spend more time in estrous than age -matched wild type females . Also , we have observed that leaner mice became pregnant less readily than wild type mice , but once pregnant , female leaner mice produced more pups per litter compared with wild type mice . The number of corpora lutea observed in leaner mice is greater than in wild type mice . In leaner mice , the number of corpora lutea in the ovary corresponding to the uterine horn with the highest number of offspring is larger than the number of corpora lutea found in the ovary corresponding to the other uterine horn . Radioimmunoassays of estradiol hormone levels at postnatal day 28 shows higher levels in leaner compared to age -matched wild type mice . However , at postnatal day 28 , the luteinizing hormone levels are similar in both categories of mice . This study of reproductive dysfunction in leaner mice was performed to gain further understanding about the role of intracellular calcium ion signaling in neuronal regulation of reproductive processes in females . en_US
dc.format.extent 805272 bytes
dc.format.medium electronic en_US
dc.format.mimetype application /pdf
dc.language.iso en _US en_US
dc.publisher Texas A &M University en_US
dc.subject leaner en_US
dc.title Abnormal reproductive function in female homozygous leaner mice en_US
dc.type Book en
dc.type.genre Electronic Thesis en_US
dc.type.material text en_US
dc.format.digitalOrigin born digital en_US

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Abnormal reproductive function in female homozygous leaner mice. Available electronically from http : / /hdl .handle .net /1969 .1 /559 .

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