Beta dose calculation in human arteries for various brachytherapy seed types

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dc.contributor.advisor Reece , W . Daniel en_US
dc.contributor.committeeMember Braby , Lesli A . en_US
dc.creator Lee , Sung -Woo en_US 2004 -09 -30T01 :40 :47Z 2014 -02 -18T22 :28 :05Z 2004 -09 -30T01 :40 :47Z 2014 -02 -18T22 :28 :05Z 2003 -05 en_US 2004 -09 -30T01 :40 :47Z
dc.identifier.uri http : / /hdl .handle .net /1969 .1 /42
dc.description.abstract This dissertation explores beta dose profile of microspheres packed in arteries , various source geometries of 142Pr that can be used for therapeutic purpose , and dose backscatter factors for selected beta sources . A novel treatment method by injecting microspheres into feeding arteries of arteriovenous malformation (AVM ) is under pre -clinical investigation . To optimize radiation dose to the clinically important area , i .e . arterial wall , preliminary dosimetric studies were needed . Monte Carlo calculations were performed for several geometries simulating arteries filled with microspheres packed by random packing methods . Arterial radii used in the simulation varied from 50 mm to 3 mm ; microsphere radii varied from 10 mm to 0 .7 mm . Dose varied significantly as a function of microsphere size , for constant arterial sizes . For the same sizes of arteries , significant dose increase was observed because of inter -artery exposure for large arteries ( > 0 .1 cm rad . ) filled with large microspheres ( > 0 .03 cm rad . ) . Dose increase between small arteries (0 .03 cm rad . ) was less significant . The dose profiles of prototype 142Pr beta brachytherapy sources were calculated using MCNP 4C Monte Carlo code as well as dose point kernel (DPK ) for selected cases . Dose profiles were similar to beta sources currently used indicating that 142Pr can substitute for current sources for certain cases and the DPK was closely matched with MCNP result . Backscattering of electrons is a prominent secondary effect in beta dosimetry . The backscattering is closely correlated with factors such as geometry of source and scattering material , and composition of scattering material . The backscattering factors were calculated for selected beta sources that are currently used as well as potentially useful sources for therapeutic purpose . The factors were calculated as a function of distance from the interface between water and scatterers . These factors were fit by a simple function for future incorporation into a DPK code . Backscattering effect was significant for short distance from the surface of interface between water and scattering material . en_US
dc.format.extent 1738890 bytes
dc.format.medium electronic en_US
dc.format.mimetype application /pdf
dc.language.iso en _US en_US
dc.publisher Texas A &M University en_US
dc.subject beta en_US
dc.title Beta dose calculation in human arteries for various brachytherapy seed types en_US
dc.type Book en
dc.type.genre Electronic Dissertation en_US
dc.type.material text en_US
dc.format.digitalOrigin born digital en_US


Beta dose calculation in human arteries for various brachytherapy seed types. Available electronically from http : / /hdl .handle .net /1969 .1 /42 .

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