Effect of HZE radiation and diets rich in fiber and n-3 poly unsaturated fatty acids (n-3 PUFA) on colon cancer in rats

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Title: Effect of HZE radiation and diets rich in fiber and n-3 poly unsaturated fatty acids (n-3 PUFA) on colon cancer in rats
Author: Glagolenko, Anna Anatolievna
Abstract: This study examines the carcinogenic effect of HZE radiation and protective effects of different types of diets against colon carcinogenesis in a rat model . The effect of HZE radiation on health state and colon cancer development was evaluated . HZE radiation was found to suppress food consumption (P <0 .0001 ) leading to lower body weight gain of irradiated rats when compared to the non -irradiated rats (P <0 .05 ) . The animals exposed to HZE radiation were found to start dying and /or getting pathologies 11 weeks earlier and at the end of the study had morbidity /mortality rate 14 .2 % higher (P=0 .0005 ) than non -irradiated rats . There was no significant effect of HZE radiation on colon cancer incidence . The effects of dietary fibers and oils on health state and colon carcinogenesis were evaluated . Morbidity /mortality was found to be delayed in rats fed with pectinbased diets when compared to cellulose -based diet , regardless of radiation treatment . Similarly , fish oil was found to beneficially affect health of the experimental animals when compared to corn oil . Ten - and twenty -week delayed morbidity /mortality for irradiated and non -irradiated groups , respectively , was observed for rats fed with fish oil -based diets when compared to corn oil -based diets . Fish oil was also found to significantly reduce colon tumor incidence and multiplicity in non -irradiated rats (P <0 .05 ) . A similar trend was observed for the irradiated animals . No significant effect of fiber on colon cancer incidence was found . Finally , the effect of diets on general health and colon cancer development was investigated . Rats fed with corn oil /cellulose diet started dying and /or getting a disease earlier than rats fed with other diets , regardless of radiation treatment . The effect of diet on colon cancer development was found to depend on radiation treatment . Thus , in the absence of radiation treatment fish oil /cellulose was found to significantly reduce tumor incidence and multiplicity when compared to corn oil /pectin diet (P <0 .05 ) . In the presence of radiation treatment fish oil /pectin was found to lower the values of tumor incidence and tumor multiplicity , though the data obtained were not significant .
URI: http : / /hdl .handle .net /1969 .1 /3942
Date: 2006-08-16

Citation

Effect of HZE radiation and diets rich in fiber and n-3 poly unsaturated fatty acids (n-3 PUFA) on colon cancer in rats. Available electronically from http : / /hdl .handle .net /1969 .1 /3942 .

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