N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes

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dc.contributor.advisor Darensbourg , Marcetta Y . en_US
dc.contributor.committeeMember Gabbai , Francois P . en_US
dc.creator Chiang , Chao -Yi en_US
dc.date.accessioned 2006 -08 -16T19 :09 :21Z
dc.date.accessioned 2014 -02 -19T19 :25 :45Z
dc.date.available 2006 -08 -16T19 :09 :21Z
dc.date.available 2014 -02 -19T19 :25 :45Z
dc.date.created 2003 -05 en_US
dc.date.issued 2006 -08 -16T19 :09 :21Z
dc.identifier.uri http : / /hdl .handle .net /1969 .1 /3920
dc.description.abstract Nitric oxide plays an important role in many biological functions . A metallo derivative in biological systems is a protein -bound dinitrosyl iron complex (DNIC ) , which results from iron -sulfur cluster degradation in the presence of excess NO . Through model complexes I have examined the fundamental properties of a dithiolato -Fe (NO )2 complex , bismercaptoethandiazacyclooctane iron dinitrosyl or (H+bme -daco )Fe (NO )2 as a biomimic of dicysteinate coordination of [Fe (NO )2] . This complex was prepared and fully characterized in my studies . The DNIC moiety is in its oxidized state , {Fe (NO )2}9 . Through reaction studies , monitored by IR spectroscopy (H+N2S2 )Fe (NO )2 (N2S2 = bme -dach . Bme -pda ) has been shown to transfer NO to FeIII in (TPP )FeCl (TPP = meso -tetraphenylporphyrin ) as NO - . The remaining mononitrosyl converts into complex (N2S2 )Fe (NO ) . The (N2S2 )Fe (NO ) complexes (N2S2 = bme -daco , bme* -daco , bme -dach ) were prepared by direct reaction of dimeric [ (N2S2 )Fe]2 and NO gas . The analogous (N2S2 )Co (NO ) complex (N2S2 = bme -dach ) has also been prepared . The series of square pyramidal (N2S2 )M (NO ) have been studied by cyclic voltammetry and & #957 ; (NO ) IR spectroscopy . en_US
dc.format.extent 3713762 bytes
dc.format.medium electronic en_US
dc.format.mimetype application /pdf
dc.language.iso en _US en_US
dc.publisher Texas A &M University en_US
dc.subject N2S2 en_US
dc.title N2s2 chelating agents as cys -x -cys biomimics for fe (no ) and fe (no )2 complexes en_US
dc.type Book en
dc.type.genre Electronic Dissertation en_US
dc.type.material text en_US
dc.format.digitalOrigin born digital en_US

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N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes. Available electronically from http : / /hdl .handle .net /1969 .1 /3920 .

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