N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes

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Title: N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes
Author: Chiang, Chao-Yi
Abstract: Nitric oxide plays an important role in many biological functions . A metallo derivative in biological systems is a protein -bound dinitrosyl iron complex (DNIC ) , which results from iron -sulfur cluster degradation in the presence of excess NO . Through model complexes I have examined the fundamental properties of a dithiolato -Fe (NO )2 complex , bismercaptoethandiazacyclooctane iron dinitrosyl or (H+bme -daco )Fe (NO )2 as a biomimic of dicysteinate coordination of [Fe (NO )2] . This complex was prepared and fully characterized in my studies . The DNIC moiety is in its oxidized state , {Fe (NO )2}9 . Through reaction studies , monitored by IR spectroscopy (H+N2S2 )Fe (NO )2 (N2S2 = bme -dach . Bme -pda ) has been shown to transfer NO to FeIII in (TPP )FeCl (TPP = meso -tetraphenylporphyrin ) as NO - . The remaining mononitrosyl converts into complex (N2S2 )Fe (NO ) . The (N2S2 )Fe (NO ) complexes (N2S2 = bme -daco , bme* -daco , bme -dach ) were prepared by direct reaction of dimeric [ (N2S2 )Fe]2 and NO gas . The analogous (N2S2 )Co (NO ) complex (N2S2 = bme -dach ) has also been prepared . The series of square pyramidal (N2S2 )M (NO ) have been studied by cyclic voltammetry and & #957 ; (NO ) IR spectroscopy .
URI: http : / /hdl .handle .net /1969 .1 /3920
Date: 2006-08-16

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N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes. Available electronically from http : / /hdl .handle .net /1969 .1 /3920 .

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