Studies of phase separable soluble polymers

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Title: Studies of phase separable soluble polymers
Author: Furyk, Steven Michael
Abstract: The technique of phase labeling has the ability to greatly enhance synthetic protocol by simplifying purification and increasing efficiency . Traditional insoluble supports offer efficient and simple recovery of the ? ?phase tagged ? ? material but suffer from problems inherent to their heterogeneous nature . A solution to these problems has been to utilize phase separable soluble polymers in the design of ? ?smart ? ? responsive systems that offer the option of homogenous reaction conditions with heterogeneous separation conditions . The subject of this dissertation focuses on the application of soluble polymeric phase tags in systems where the miscibility between solid -liquid and liquid -liquid systems is thermally induced . Low molecular weight poly (ethylene glycol ) (PEG ) oligomers were investigated as phase anchors for SCS palladacycle catalysts . The oligomeric PEG chains were sufficient to engender polar phase solubility in a heptane -DMA thermomorphic system . Microwave irradiation of these thermomorphic mixtures of palladium complexes and substrates was a viable scheme to recycle and significantly shorten reaction times for simple Heck reactions of aryl iodides . Soluble polymeric supports possessing a lower critical solution temperature (LCST ) were utilized in the sequestration of the S -triazine herbicide , atrazine , from contaminated water samples . The ability of poly (N -isopropylacrylamide ) to sequester hydrophobic guests like atrazine was examined . A functionalized PNIPAM derivative containing secondary cyclic amines exhibited superior sequestration ability that was credited to the covalent binding of the atrazine . In order to facilitate the design of tailored , thermally responsive , smart polymers , a high throughput temperature gradient microfluidic device was used to obtain LCST data in a fast , accurate manner . The specific ion effects of various alkali metal halide salts on the LCST of PNIPAM were investigated . The high precision in the measurements enabled more subtle effects such as changes in solvent isotope , polymer microstructure , molecular weight , and importance of end group effects on the LCST of poly (N -alkylacrylamide )s to be evaluated .
URI: http : / /hdl .handle .net /1969 .1 /3860
Date: 2006-08-16

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Studies of phase separable soluble polymers. Available electronically from http : / /hdl .handle .net /1969 .1 /3860 .

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