Associative tolerance to nicotine's analgesic effects: studies on number of conditioning trials and corticosterone

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dc.contributor.advisor Cepeda -Benito , Antonio en_US
dc.contributor.committeeMember Wellman , Paul en_US
dc.creator Davis , Kristina en_US
dc.date.accessioned 2004 -09 -30T01 :40 :36Z
dc.date.accessioned 2014 -02 -18T22 :28 :04Z
dc.date.available 2004 -09 -30T01 :40 :36Z
dc.date.available 2014 -02 -18T22 :28 :04Z
dc.date.created 2003 -08 en_US
dc.date.issued 2004 -09 -30T01 :40 :36Z
dc.identifier.uri http : / /hdl .handle .net /1969 .1 /32
dc.description.abstract This study examined the number of conditioning trials necessary to produce associative nicotine tolerance and the changes in corticosterone levels during the procedures . Six independent groups of rats (N = 355 ) were run through tolerance acquisition procedures for 1 , 5 , or 10 conditioning sessions . Treatment groups were comprised of animals that received nicotine -environment pairings , animals that received nicotine explicitly unpaired with the drug administration environment , and control groups that received either saline throughout or no treatment . Three of the groups were tested for nicotine -induced analgesia using the tail -flick and hot -plate assays , and three groups were blood sampled after either nicotine or saline injection . Pairing of environment with nicotine produced greater tolerance for rats after 5 conditioning sessions in the tail flick and after 10 conditioning sessions in the hot -plate . Corticosterone levels were elevated in all rats given nicotine . Rats that received the nicotine -environment pairing showed a conditioned release of corticosterone in response the environment after both 5 and 10 conditioning sessions . en_US
dc.format.extent 210906 bytes
dc.format.medium electronic en_US
dc.format.mimetype application /pdf
dc.language.iso en _US en_US
dc.publisher Texas A &M University en_US
dc.subject nicotine tolerance en_US
dc.title Associative tolerance to nicotine's analgesic effects : studies on number of conditioning trials and corticosterone en_US
dc.type Book en
dc.type.genre Electronic Thesis en_US
dc.type.material text en_US
dc.format.digitalOrigin born digital en_US

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Associative tolerance to nicotine's analgesic effects: studies on number of conditioning trials and corticosterone. Available electronically from http : / /hdl .handle .net /1969 .1 /32 .

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