Safety and efficacy of NovaSil clay as a dietary supplement to prevent aflatoxicosis

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dc.contributor.advisor Phillips , Timothy D . en_US
dc.contributor.committeeMember Price , Ed . C . en_US
dc.creator Afriyie -Gyawu , Evans en_US 2006 -04 -12T16 :04 :12Z 2014 -02 -19T19 :24 :50Z 2006 -04 -12T16 :04 :12Z 2014 -02 -19T19 :24 :50Z 2004 -12 en_US 2006 -04 -12T16 :04 :12Z
dc.identifier.uri http : / /hdl .handle .net /1969 .1 /3192
dc.description.abstract It is well documented that aflatoxin contamination in foods presents significant economic and public health burdens worldwide . Aflatoxins , particularly aflatoxin B1 (AFB1 ) , have been implicated in the etiology of disease and death in many parts of the world , necessitating research initiatives for intervention strategies designed to diminish biological exposure . Calcium montmorillonite clays (e .g . NovaSil Plus , NSP ) have been found to tightly bind and inactivate aflatoxins in the gastrointestinal tract of multiple animal species . In the future , the hypothesis is that this strategy may also be appropriate for humans . Thus , the overall research goal was to investigate NSP suitability for human use through in vitro characterization followed by in vivo evaluation of NSP -AFB1 sorption and most importantly , safety of the clay . The first objective was to characterize the in vitro and in vivo sorption efficiency of NSP -AFB1 sorption and determine potential interactions with vitamin A (VA ) . Isothermal analysis suggested that NSP binds AFB1 with high capacity , affinity , and specificity in aqueous solution and further indicated that NSP does not appear to interact with VA . Subsequent short -term studies in Sprague -Dawley (S -D ) rats and broiler chicks indicated that dietary inclusion of NSP (0 .25 % ) significantly reduced AFB1 bioavailability without exerting overt toxicity . The second objective was to evaluate potential adverse effects of chronic ingestion of dietary NSP using male and female S -D rats in the absence of aflatoxins . Although statistically significant changes to a few parameters were noted , the differences did not appear to be NSP - or dose -dependent , suggesting that NSP at dietary inclusion levels as great as 2 .0 % (w /w ) does not produce overt toxicity . Thus , this information increases the feasibility for using NSP in human trials in populations at high risk for aflatoxicosis . The third objective was to establish representative baseline data on human exposure to aflatoxins by collecting and quantifying urinary AFM1 in volunteers living in four separate communities in Ejura district of Ghana . Results revealed that urinary AFM1 in the study population was substantially high (mean = 1 ,850 .86 ? ? 274 .59 pg /mg creatinine ) , indicating that this particular population was highly exposed to aflatoxins and could be used for future intervention trials . en_US
dc.format.extent 3726115 bytes
dc.format.medium electronic en_US
dc.format.mimetype application /pdf
dc.language.iso en _US en_US
dc.publisher Texas A &M University en_US
dc.subject Aflatoxins en_US
dc.title Safety and efficacy of NovaSil clay as a dietary supplement to prevent aflatoxicosis en_US
dc.type Book en
dc.type.genre Electronic Dissertation en_US
dc.type.material text en_US
dc.format.digitalOrigin born digital en_US


Safety and efficacy of NovaSil clay as a dietary supplement to prevent aflatoxicosis. Available electronically from http : / /hdl .handle .net /1969 .1 /3192 .

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