Catalysts for the hydrolysis of thiophosphate triesters

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Title: Catalysts for the hydrolysis of thiophosphate triesters
Author: Picot, Alexandre
Abstract: The degradation of phosphate triesters is efficiently catalyzed by organophosphate hydrolases (OPH ) . While a number of recent studies have focused on optimizing the rate of hydrolysis observed with the native enzyme , no dinuclear complexes that mimic the function of OPH have been reported or investigated . Our present research focuses on the synthesis of dinuclear metal complexes and on the study of their catalytic abilities . An important aspect of this research concerns the investigation of the coordination chemistry of dinuclear ligands designed to hold two metal cations in well defined positions . The ability of the different complexes to catalyze the degradation of thiophosphate triester is presented . Out of several complexes studied , ortho -metallated Pd (II ) complexes have been found to display the highest catalytic activity for the hydrolysis of parathion .
URI: http : / /hdl .handle .net /1969 .1 /1436
Date: 2005-02-17

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Catalysts for the hydrolysis of thiophosphate triesters. Available electronically from http : / /hdl .handle .net /1969 .1 /1436 .

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